Dopamine D(2/3) receptor availability and human cognitive impulsivity: a high-resolution positron emission tomography imaging study with [¹¹C]raclopride.
Acta Neuropsychiatr
; 26(1): 35-42, 2014 Feb.
Article
em En
| MEDLINE
| ID: mdl-25142098
ABSTRACT
OBJECTIVE:
Human impulsivity is a complex multidimensional construct encompassing cognitive, emotional, and behavioural aspects. Previous animal studies have suggested that striatal dopamine receptors play a critical role in impulsivity. In this study, we investigated the relationship between self-reported impulsiveness and dopamine D(2/3) receptor availability in striatal subdivisions in healthy subjects using high-resolution positron emission tomography (PET) with [11C]raclopride.METHODS:
Twenty-one participants completed 3-T magnetic resonance imaging and high-resolution PET scans with [11C]raclopride. The trait of impulsiveness was measured using the Barratt Impulsiveness Scale (BIS-11). Partial correlation analysis was performed between BIS-11 scores and D(2/3) receptor availability in striatal subregions, controlling for the confounding effects of temperament characteristics that are conceptually or empirically related to dopamine, which were measured by the Temperament and Character Inventory.RESULTS:
The analysis revealed that the non-planning (p = 0.004) and attentional (p = 0.007) impulsiveness subscale scores on the BIS-11 had significant positive correlations with D(2/3) receptor availability in the pre-commissural dorsal caudate. There was a tendency towards positive correlation between non-planning impulsiveness score and D(2/3) receptor availability in the post-commissural caudate.CONCLUSION:
These results suggest that cognitive subtrait of impulsivity is associated with D(2/3) receptor availability in the associative striatum that plays a critical role in cognitive processes involving attention to detail, judgement of alternative outcomes, and inhibitory control.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Receptores de Dopamina D2
/
Corpo Estriado
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Receptores de Dopamina D3
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Comportamento Impulsivo
Limite:
Adult
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Female
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Humans
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Male
Idioma:
En
Revista:
Acta Neuropsychiatr
Ano de publicação:
2014
Tipo de documento:
Article