Putting J chain back on the map: how might its expression define plasma cell development?
J Immunol
; 193(7): 3248-55, 2014 Oct 01.
Article
em En
| MEDLINE
| ID: mdl-25240020
ABSTRACT
Joining chain (J chain) is a small polypeptide that regulates multimerization of secretory IgM and IgA, the only two mammalian Igs capable of forming multimers. J chain also is required for poly-Ig receptor-mediated transport of these Ig classes across the mucosal epithelium. It is generally assumed that all plasma cells express J chain regardless of expressed isotype, despite the documented presence of J chain(-) plasma cells in mammals, specifically in all monomeric IgA-secreting cells and some IgG-secreting cells. Compared with most other immune molecules, J chain has not been studied extensively, in part because of technical limitations. Even the reported phenotype of the J chain-knockout mouse is often misunderstood or underappreciated. In this short review, we discuss J chain in light of the various proposed models of its expression and regulation, with an added focus on its evolutionary significance, as well as its expression in different B cell lineages/differentiation states.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Plasmócitos
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Imunoglobulina A
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Imunoglobulina M
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Regulação da Expressão Gênica
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Cadeias J de Imunoglobulina
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Receptores de Imunoglobulina Polimérica
Limite:
Animals
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Humans
Idioma:
En
Revista:
J Immunol
Ano de publicação:
2014
Tipo de documento:
Article