Antibiotic Dosing in Patients With Acute Kidney Injury: "Enough But Not Too Much".
J Intensive Care Med
; 31(3): 164-76, 2016 Mar.
Article
em En
| MEDLINE
| ID: mdl-25326429
ABSTRACT
Increasing evidence suggests that antibiotic dosing in critically ill patients with acute kidney injury (AKI) often does not achieve pharmacodynamic goals, and the continued high mortality rate due to infectious causes appears to confirm these findings. Although there are compelling reasons why clinicians should use more aggressive antibiotic dosing, particularly in patients receiving aggressive renal replacement therapies, concerns for toxicity associated with higher doses are real. The presence of multisystem organ failure and polypharmacy predispose these patients to drug toxicity. This article examines the pharmacokinetic and pharmacodynamic consequences of critical illness, AKI, and renal replacement therapy and describes potential solutions to help clinicians give "enough but not too much" in these very complicated patients.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Terapia de Substituição Renal
/
Sepse
/
Injúria Renal Aguda
/
Antibacterianos
/
Insuficiência de Múltiplos Órgãos
Tipo de estudo:
Guideline
Limite:
Humans
Idioma:
En
Revista:
J Intensive Care Med
Assunto da revista:
TERAPIA INTENSIVA
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Estados Unidos