[Association between gene polymorphism of CD40 gene and coronary artery lesion in Kawasaki disease].
Zhongguo Dang Dai Er Ke Za Zhi
; 16(10): 1025-8, 2014 Oct.
Article
em Zh
| MEDLINE
| ID: mdl-25344184
ABSTRACT
OBJECTIVE:
To study the association between two single nucleotide polymorphisms (rs4810485 and rs1535045 in CD40 gene) and Kawasaki disease (KD) in Han Chinese children.METHODS:
A case-control study was performed on 184 children with KD and 206 normal controls. The polymorphisms of two SNPs in CD40 gene were detected using PCR-RFLP.RESULTS:
There were no significant differences in the genotype distribution and allele frequency of SNP rs4810485 in CD40 gene between the KD and normal groups (P>0.05). The genotype distribution of SNP rs1535045 in CD40 gene in the KD group was significantly different from the control group (P<0.05). T allele of SNP rs1535045 was shown as a risk factor for development of KD (OR=1.592, 95%CI 1.182-2.144, P=0.004). There were no association between the polymorphisms of the two SNPs and coronary artery lesions (P>0.05).CONCLUSIONS:
SNP rs1535045 may be associated with the development of KD in Han Chinese children, while SNP rs4810485 may not.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença da Artéria Coronariana
/
Antígenos CD40
/
Polimorfismo de Nucleotídeo Único
/
Síndrome de Linfonodos Mucocutâneos
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Idioma:
Zh
Revista:
Zhongguo Dang Dai Er Ke Za Zhi
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
China