Enantioselective total synthesis of the lignan (+)-linoxepin.
Chemistry
; 20(51): 17119-24, 2014 Dec 15.
Article
em En
| MEDLINE
| ID: mdl-25345835
ABSTRACT
An enantioselective total synthesis of the natural (+)-linoxepin (1) was accomplished in eleven steps from bromovanin (24). Key steps are a domino carbopalladation/ Mizoroki-Heck reaction with the formation of a pentacyclic system, an asymmetric hydroboration as well as an oxidative lactonization.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Compostos Policíclicos
/
Benzaldeídos
/
Lignanas
Idioma:
En
Revista:
Chemistry
Assunto da revista:
QUIMICA
Ano de publicação:
2014
Tipo de documento:
Article