Pharmacokinetic evaluation of tenofovir disoproxil fumarate released from an intravaginal ring in pigtailed macaques after 6 months of continuous use.
J Med Primatol
; 43(5): 364-9, 2014 Oct.
Article
em En
| MEDLINE
| ID: mdl-25379594
ABSTRACT
BACKGROUND AND METHODS:
A reservoir intravaginal ring (IVR) eluting tenofovir disoproxil fumarate (TDF) was evaluated for 6 months of continuous use in normally cycling female pigtailed macaques with monthly IVR exchanges to define pharmacokinetics and safety. RESULTS ANDCONCLUSIONS:
Tenofovir levels in vaginal secretions and tissue remained consistent for 6 months with no adverse safety concerns.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Adenina
/
Infecções por Lentivirus
/
HIV
/
Vírus da Imunodeficiência Símia
/
Fármacos Anti-HIV
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Organofosfonatos
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Macaca nemestrina
Limite:
Animals
Idioma:
En
Revista:
J Med Primatol
Ano de publicação:
2014
Tipo de documento:
Article