Accumulation of cAMP in the cells of Candida tropicalis at an early stage of ethanol-induced filamentous growth and its prevention by myo-inositol.
Biochem Biophys Res Commun
; 162(2): 646-50, 1989 Jul 31.
Article
em En
| MEDLINE
| ID: mdl-2547368
ABSTRACT
Phosphatidylinositol metabolism is enhanced in the cells of Candida tropicalis Pk 233 at an early stage of filamentous growth caused by ethanol, and myo-inositol prevents the ethanol-induced changes in the metabolism and morphology [Uejima et al. (1987) FEBS Lett. 214, 127-129]. The accumulation of cAMP and an increase in adenylate cyclase activity were observed in the cells grown with ethanol to the mid-log phase. Myo-inositol abolished these effects of ethanol also. The activity of cAMP phosphodiesterase was affected by neither ethanol nor myo-inositol. These results suggest that the inositol phospholipid-linked and cAMP-linked signaling pathways may be involved in the mechanism of ethanol-induced filamentous growth of this yeast and also that myo-inositol would affect morphogenesis by controlling these pathways.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Candida
/
AMP Cíclico
/
Etanol
/
Inositol
Idioma:
En
Revista:
Biochem Biophys Res Commun
Ano de publicação:
1989
Tipo de documento:
Article
País de afiliação:
Japão