High-syn conformation of uridine and asymmetry of the hexameric molecule revealed in the high-resolution structures of Shewanella oneidensis MR-1 uridine phosphorylase in the free form and in complex with uridine.

Safonova, Tatyana N; Mikhailov, Sergey N; Veiko, Vladimir P; Mordkovich, Nadezhda N; Manuvera, Valentin A; Alekseev, Cyril S; Kovalchuk, Mikhail V; Popov, Vladimir O; Polyakov, Konstantin M

Safonova, Tatyana N; Mikhailov, Sergey N; Veiko, Vladimir P; Mordkovich, Nadezhda N; Manuvera, Valentin A; Alekseev, Cyril S; Kovalchuk, Mikhail V; Popov, Vladimir O; Polyakov, Konstantin M.

Afiliação

Safonova TN; Bach Institute of Biochemistry, Russian Academy of Sciences, 33 Leninskii Ave., Moscow 119071, Russian Federation.
Mikhailov SN; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 32 Vavilova St., Moscow 119991, Russian Federation.
Veiko VP; Bach Institute of Biochemistry, Russian Academy of Sciences, 33 Leninskii Ave., Moscow 119071, Russian Federation.
Mordkovich NN; Bach Institute of Biochemistry, Russian Academy of Sciences, 33 Leninskii Ave., Moscow 119071, Russian Federation.
Manuvera VA; Research Institute for Physico-Chemical Medicine, Federal Medical-Biological Agency, 1a Malaya Pirogovskaya St., Moscow 119435, Russian Federation.
Alekseev CS; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 32 Vavilova St., Moscow 119991, Russian Federation.
Kovalchuk MV; National Research Centre `Kurchatov Institute', 1 Pl. Akademika Kurchatova, Moscow 123182, Russian Federation.
Popov VO; Bach Institute of Biochemistry, Russian Academy of Sciences, 33 Leninskii Ave., Moscow 119071, Russian Federation.
Polyakov KM; Bach Institute of Biochemistry, Russian Academy of Sciences, 33 Leninskii Ave., Moscow 119071, Russian Federation.

Acta Crystallogr D Biol Crystallogr ; 70(Pt 12): 3310-9, 2014 Dec 01.

Article em En | MEDLINE | ID: mdl-25478848

Assuntos

Shewanella/enzimologia; Uridina Fosforilase/química; Uridina/metabolismo; Domínio Catalítico; Cristalografia por Raios X; Infecções por Bactérias Gram-Negativas/microbiologia; Humanos; Conformação Proteica; Shewanella/química; Shewanella/metabolismo; Uridina/química; Uridina Fosforilase/metabolismo

Palavras-chave

Shewanella oneidensis MR-1; atomic resolution; crystallization under microgravity; high-syn conformation of uridine; twinning; uridine phosphorylase

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Uridina / Uridina Fosforilase / Shewanella Limite: Humans Idioma: En Revista: Acta Crystallogr D Biol Crystallogr Ano de publicação: 2014 Tipo de documento: Article

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