[Digestive system disease as manifestation of the pleiotropic action of genes in mitochondrial dysfunction].
Lik Sprava
; (11): 29-39, 2014 Nov.
Article
em Uk
| MEDLINE
| ID: mdl-25528830
ABSTRACT
Defined involvement lesions of the digestive system of clinical manifestations of mitochondrial dysfunction associated with both point mutations and polymorphism of mitochondrial DNA. The nature of the clinical signs of mtDNA polymorphisms carriers--multi organical, a progressive, clinical polymorphism, genetic heterogeneity with predominant involvement of energotropic bodies (cerebrum, cordis, hepatic). Set individual nosological forms of mitochondrial dysfunctions--syndromes Leia, Leber, Cairns, Sarah, MERRF, MELAS, NARP, MNGIE confirmed by clinical and genetic, morphological, biochemical, enzymatic, molecular genetics methods. It was found that 84-88% of these syndromes involving the violation of the digestive system with varying degrees of injury. This damage will be the first in the complex chain signs recovery which determines the direction of early rehabilitation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
DNA Mitocondrial
/
Pleiotropia Genética
/
Gastroenteropatias
/
Mitocôndrias
Idioma:
Uk
Revista:
Lik Sprava
Assunto da revista:
MEDICINA
Ano de publicação:
2014
Tipo de documento:
Article