High-speed DNA sequencing: an approach based upon fluorescence detection of single molecules.
J Biomol Struct Dyn
; 7(2): 301-9, 1989 Oct.
Article
em En
| MEDLINE
| ID: mdl-2557861
ABSTRACT
We are developing a laser based technique for the rapid sequencing of large fragments (approximately 40 kb) of DNA based upon the detection of single, fluorescently tagged nucleotides cleaved from a single DNA fragment. We have demonstrated significant progress on several of the important steps of this technique. The projected rate of sequencing is several hundred bases per second which is orders of magnitude faster than existing methods. Once developed, this technology could be utilized by investigators for rapid sequencing of genetic material from virtually any source.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
DNA
/
Sequência de Bases
Tipo de estudo:
Diagnostic_studies
Idioma:
En
Revista:
J Biomol Struct Dyn
Ano de publicação:
1989
Tipo de documento:
Article