Combinational deletion of three membrane protein-encoding genes highly attenuates yersinia pestis while retaining immunogenicity in a mouse model of pneumonic plague.

Tiner, Bethany L; Sha, Jian; Kirtley, Michelle L; Erova, Tatiana E; Popov, Vsevolod L; Baze, Wallace B; van Lier, Christina J; Ponnusamy, Duraisamy; Andersson, Jourdan A; Motin, Vladimir L; Chauhan, Sadhana; Chopra, Ashok K

Tiner, Bethany L; Sha, Jian; Kirtley, Michelle L; Erova, Tatiana E; Popov, Vsevolod L; Baze, Wallace B; van Lier, Christina J; Ponnusamy, Duraisamy; Andersson, Jourdan A; Motin, Vladimir L; Chauhan, Sadhana; Chopra, Ashok K.

Afiliação

Tiner BL; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA.
Sha J; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas, USA jisha@utmb.edu achopra@utmb.edu.
Kirtley ML; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA.
Erova TE; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA.
Popov VL; Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA.
Baze WB; Department of Veterinary Sciences, University of Texas M. D. Anderson Cancer Center, Bastrop, Texas, USA.
van Lier CJ; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA.
Ponnusamy D; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA.
Andersson JA; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA.
Motin VL; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas, USA Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA Center for Va
Chauhan S; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA.
Chopra AK; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas, USA Center for Vaccine Development, University of Texas Medical Branch, Galveston, Texas, USA Center

Infect Immun ; 83(4): 1318-38, 2015 Apr.

Article em En | MEDLINE | ID: mdl-25605764

Assuntos

Aciltransferases/genética; Proteínas da Membrana Bacteriana Externa/genética; Lipoproteínas/genética; Peste/imunologia; Fatores de Virulência/genética; Yersinia pestis/patogenicidade; Animais; Antibacterianos/farmacologia; Anticorpos Antibacterianos/imunologia; Aderência Bacteriana/genética; Aderência Bacteriana/imunologia; Linhagem Celular; Modelos Animais de Doenças; Farmacorresistência Bacteriana/genética; Feminino; Deleção de Genes; Gentamicinas/farmacologia; Células HeLa; Humanos; Espaço Intracelular/microbiologia; Macrófagos/imunologia; Macrófagos/microbiologia; Camundongos; Peste/patologia; Yersinia pestis/genética; Yersinia pestis/imunologia

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peste / Proteínas da Membrana Bacteriana Externa / Yersinia pestis / Aciltransferases / Fatores de Virulência / Lipoproteínas Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Infect Immun Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos

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