An Eco RI polymorphic site in the human complement C4 gene distinguishes juvenile rheumatoid arthritis (JRA) susceptibility-bearing haplotypes.
Mol Immunol
; 26(4): 427-30, 1989 Apr.
Article
em En
| MEDLINE
| ID: mdl-2566114
ABSTRACT
Susceptibility to acquire Juvenile Rheumatoid Arthritis (JRA) is linked to HLA-DR5 and DRw8 antigens in Caucasoid populations. However, the frequency of HLA-DR5 is too high in the normal Spanish population and JRA cannot thus be found to be associated with this antigen. It has been found a 14.3 kb-C4-Eco RI restriction fragment length polymorphism which correlates significantly with JRA and may be used as a marker for this disorder in Spaniards.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polimorfismo Genético
/
Artrite Juvenil
/
Polimorfismo de Fragmento de Restrição
/
Complemento C4
/
Genes
Limite:
Child
/
Humans
Idioma:
En
Revista:
Mol Immunol
Ano de publicação:
1989
Tipo de documento:
Article
País de afiliação:
Espanha