Hesperetin derivative-7 inhibits PDGF-BB-induced hepatic stellate cell activation and proliferation by targeting Wnt/ß-catenin pathway.

Lin, Xiang; Kong, Ling-Na; Huang, Cheng; Ma, Tao-Tao; Meng, Xiao-Ming; He, Yong; Wang, Qian-Qian; Li, Jun

Lin, Xiang; Kong, Ling-Na; Huang, Cheng; Ma, Tao-Tao; Meng, Xiao-Ming; He, Yong; Wang, Qian-Qian; Li, Jun.

Afiliação

Lin X; School of Pharmacy, Anhui Medical University, Meishan Road, Hefei 230032, China; Institute for Liver Diseases of Anhui Medical University (AMU), China; Institute for Innovative Drug Industrial Generic Technology Research of Anhui, Hefei 230032, China.
Kong LN; School of Pharmacy, Anhui Medical University, Meishan Road, Hefei 230032, China; Institute for Liver Diseases of Anhui Medical University (AMU), China; Institute for Innovative Drug Industrial Generic Technology Research of Anhui, Hefei 230032, China.
Huang C; School of Pharmacy, Anhui Medical University, Meishan Road, Hefei 230032, China; Institute for Liver Diseases of Anhui Medical University (AMU), China; Institute for Innovative Drug Industrial Generic Technology Research of Anhui, Hefei 230032, China.
Ma TT; School of Pharmacy, Anhui Medical University, Meishan Road, Hefei 230032, China; Institute for Liver Diseases of Anhui Medical University (AMU), China; Institute for Innovative Drug Industrial Generic Technology Research of Anhui, Hefei 230032, China.
Meng XM; School of Pharmacy, Anhui Medical University, Meishan Road, Hefei 230032, China; Institute for Liver Diseases of Anhui Medical University (AMU), China; Institute for Innovative Drug Industrial Generic Technology Research of Anhui, Hefei 230032, China.
He Y; School of Pharmacy, Anhui Medical University, Meishan Road, Hefei 230032, China; Institute for Liver Diseases of Anhui Medical University (AMU), China; Institute for Innovative Drug Industrial Generic Technology Research of Anhui, Hefei 230032, China.
Wang QQ; School of Pharmacy, Anhui Medical University, Meishan Road, Hefei 230032, China; Institute for Liver Diseases of Anhui Medical University (AMU), China; Institute for Innovative Drug Industrial Generic Technology Research of Anhui, Hefei 230032, China.
Li J; School of Pharmacy, Anhui Medical University, Meishan Road, Hefei 230032, China; Institute for Liver Diseases of Anhui Medical University (AMU), China; Institute for Innovative Drug Industrial Generic Technology Research of Anhui, Hefei 230032, China. Electronic address: lj@ahmu.edu.cn.

Int Immunopharmacol ; 25(2): 311-20, 2015 Apr.

Article em En | MEDLINE | ID: mdl-25701506

Assuntos

Células Estreladas do Fígado/efeitos dos fármacos; Hesperidina/análogos & derivados; Hesperidina/farmacologia; Via de Sinalização Wnt/efeitos dos fármacos; Actinas/genética; Actinas/metabolismo; Animais; Apoptose/efeitos dos fármacos; Becaplermina; Ciclo Celular/efeitos dos fármacos; Linhagem Celular; Proliferação de Células/efeitos dos fármacos; Sobrevivência Celular/efeitos dos fármacos; Colágeno Tipo I/genética; Colágeno Tipo I/metabolismo; Cadeia alfa 1 do Colágeno Tipo I; Fibrose; Células Estreladas do Fígado/fisiologia; Hesperidina/uso terapêutico; Hepatopatias/tratamento farmacológico; Hepatopatias/metabolismo; Hepatopatias/patologia; Masculino; Camundongos; Proteínas Proto-Oncogênicas c-sis

Palavras-chave

Activation; HDND-7; Proliferation; Wnt/ß-catenin signaling

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células Estreladas do Fígado / Via de Sinalização Wnt / Hesperidina Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Int Immunopharmacol Assunto da revista: ALERGIA E IMUNOLOGIA / FARMACOLOGIA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: China

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