Neuromuscular blockade with vecuronium in paediatric patients with burn injury.
Br J Clin Pharmacol
; 28(2): 155-9, 1989 Aug.
Article
em En
| MEDLINE
| ID: mdl-2570602
ABSTRACT
1. The effect of body surface area (BSA) burn injury on neuromuscular pharmacodynamics of vecuronium was evaluated. 2. The neuromuscular responses of 15 burned children were compared with those in five controls. 3. The effective dose for 50% suppression of twitch tension (ED50) was 34 micrograms kg-1 for patients with less than 40% BSA burn, 55 micrograms kg-1 for 40-60% BSA burn, and 65 micrograms kg-1 for patients with greater than 60% BSA burn. These values were significantly higher than the value for control patients, which was 18 micrograms kg-1. 4. Burn injury induces a resistance to the neuromuscular effects of vecuronium, the magnitude of which is related to burn size.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Brometo de Vecurônio
/
Queimaduras
/
Bloqueadores Neuromusculares
Limite:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Idioma:
En
Revista:
Br J Clin Pharmacol
Ano de publicação:
1989
Tipo de documento:
Article
País de afiliação:
Marrocos