The effect of thioctic acid on allodynia in a rat vincristine-induced neuropathy model.
J Int Med Res
; 43(3): 350-5, 2015 Jun.
Article
em En
| MEDLINE
| ID: mdl-25716460
ABSTRACT
OBJECTIVE:
To investigate the antiallodynic effects of thioctic acid in vincristine-induced neuropathy in rats.METHODS:
Neuropathy was induced in Sprague-Dawley rats via vincristine intraperitoneal injection. After 15 days, rats were investigated for the presence of mechanical and cold allodynia, and those with allodynia received intraperitoneal injection with normal saline or 1, 5, or 10 mg/kg thioctic acid. Mechanical and cold allodynia were assessed before treatment and at 15, 30, 60, 90, 150 and 180 min after treatment.RESULTS:
Mechanical and cold allodynia were reduced by thioctic acid injection. The duration of effect increased with thioctic acid dose.CONCLUSION:
Thioctic acid may be an effective treatment for vincristine-induced neuropathy.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ácido Tióctico
/
Hiperalgesia
/
Inflamação
/
Anti-Inflamatórios
/
Antioxidantes
Limite:
Animals
Idioma:
En
Revista:
J Int Med Res
Ano de publicação:
2015
Tipo de documento:
Article