Decreased plasma albumin concentration results in increased volume of distribution and decreased elimination of midazolam in intensive care patients.
Clin Pharmacol Ther
; 46(5): 537-44, 1989 Nov.
Article
em En
| MEDLINE
| ID: mdl-2582710
ABSTRACT
The pharmacokinetic parameters of 16 patients in the intensive care unit, sedated with midazolam, were evaluated. A large variation was observed in the plasma concentration of midazolam and between the plasma concentration of midazolam and its metabolite 1-hydroxymethylmidazolam glucuronide. The plasma albumin concentration governs the volume of distribution of midazolam. Decreased plasma albumin concentration (25 gm/L) results in an increased volume of distribution and a decreased elimination rate of midazolam. The observed plasma concentration ratio between the parent drug and its metabolite 1-hydroxymethylmidazolam glucuronide is governed by the variables of protein binding, the metabolic rate of midazolam, and the renal clearance of the glucuronide metabolite itself (which can be considered as a measure of the kidney function of the patient).
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Midazolam
/
Albumina Sérica
Limite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Clin Pharmacol Ther
Ano de publicação:
1989
Tipo de documento:
Article
País de afiliação:
Holanda