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TREM-1 Mediates Inflammatory Injury and Cardiac Remodeling Following Myocardial Infarction.
Boufenzer, Amir; Lemarié, Jérémie; Simon, Tabassome; Derive, Marc; Bouazza, Youcef; Tran, Nguyen; Maskali, Fatiha; Groubatch, Frédérique; Bonnin, Philippe; Bastien, Claire; Bruneval, Patrick; Marie, Pierre-Yves; Cohen, Raphael; Danchin, Nicolas; Silvestre, Jean-Sébastien; Ait-Oufella, Hafid; Gibot, Sébastien.
Afiliação
  • Boufenzer A; From the Inserm UMR_S1116 (A.B., J.L., M.D., Y.B., S.G.) and School of Surgery (N. T., F. G.), Faculté de Médecine de Nancy, Université de Lorraine, Nancy, France; Medical Intensive Care Unit, Hôpital Central (J.L., S.G.), Nancyclotep, Hôpital Brabois (F.M., P.-Y.M.), and Department of Pathology, Hô
  • Lemarié J; From the Inserm UMR_S1116 (A.B., J.L., M.D., Y.B., S.G.) and School of Surgery (N. T., F. G.), Faculté de Médecine de Nancy, Université de Lorraine, Nancy, France; Medical Intensive Care Unit, Hôpital Central (J.L., S.G.), Nancyclotep, Hôpital Brabois (F.M., P.-Y.M.), and Department of Pathology, Hô
  • Simon T; From the Inserm UMR_S1116 (A.B., J.L., M.D., Y.B., S.G.) and School of Surgery (N. T., F. G.), Faculté de Médecine de Nancy, Université de Lorraine, Nancy, France; Medical Intensive Care Unit, Hôpital Central (J.L., S.G.), Nancyclotep, Hôpital Brabois (F.M., P.-Y.M.), and Department of Pathology, Hô
  • Derive M; From the Inserm UMR_S1116 (A.B., J.L., M.D., Y.B., S.G.) and School of Surgery (N. T., F. G.), Faculté de Médecine de Nancy, Université de Lorraine, Nancy, France; Medical Intensive Care Unit, Hôpital Central (J.L., S.G.), Nancyclotep, Hôpital Brabois (F.M., P.-Y.M.), and Department of Pathology, Hô
  • Bouazza Y; From the Inserm UMR_S1116 (A.B., J.L., M.D., Y.B., S.G.) and School of Surgery (N. T., F. G.), Faculté de Médecine de Nancy, Université de Lorraine, Nancy, France; Medical Intensive Care Unit, Hôpital Central (J.L., S.G.), Nancyclotep, Hôpital Brabois (F.M., P.-Y.M.), and Department of Pathology, Hô
  • Tran N; From the Inserm UMR_S1116 (A.B., J.L., M.D., Y.B., S.G.) and School of Surgery (N. T., F. G.), Faculté de Médecine de Nancy, Université de Lorraine, Nancy, France; Medical Intensive Care Unit, Hôpital Central (J.L., S.G.), Nancyclotep, Hôpital Brabois (F.M., P.-Y.M.), and Department of Pathology, Hô
  • Maskali F; From the Inserm UMR_S1116 (A.B., J.L., M.D., Y.B., S.G.) and School of Surgery (N. T., F. G.), Faculté de Médecine de Nancy, Université de Lorraine, Nancy, France; Medical Intensive Care Unit, Hôpital Central (J.L., S.G.), Nancyclotep, Hôpital Brabois (F.M., P.-Y.M.), and Department of Pathology, Hô
  • Groubatch F; From the Inserm UMR_S1116 (A.B., J.L., M.D., Y.B., S.G.) and School of Surgery (N. T., F. G.), Faculté de Médecine de Nancy, Université de Lorraine, Nancy, France; Medical Intensive Care Unit, Hôpital Central (J.L., S.G.), Nancyclotep, Hôpital Brabois (F.M., P.-Y.M.), and Department of Pathology, Hô
  • Bonnin P; From the Inserm UMR_S1116 (A.B., J.L., M.D., Y.B., S.G.) and School of Surgery (N. T., F. G.), Faculté de Médecine de Nancy, Université de Lorraine, Nancy, France; Medical Intensive Care Unit, Hôpital Central (J.L., S.G.), Nancyclotep, Hôpital Brabois (F.M., P.-Y.M.), and Department of Pathology, Hô
  • Bastien C; From the Inserm UMR_S1116 (A.B., J.L., M.D., Y.B., S.G.) and School of Surgery (N. T., F. G.), Faculté de Médecine de Nancy, Université de Lorraine, Nancy, France; Medical Intensive Care Unit, Hôpital Central (J.L., S.G.), Nancyclotep, Hôpital Brabois (F.M., P.-Y.M.), and Department of Pathology, Hô
  • Bruneval P; From the Inserm UMR_S1116 (A.B., J.L., M.D., Y.B., S.G.) and School of Surgery (N. T., F. G.), Faculté de Médecine de Nancy, Université de Lorraine, Nancy, France; Medical Intensive Care Unit, Hôpital Central (J.L., S.G.), Nancyclotep, Hôpital Brabois (F.M., P.-Y.M.), and Department of Pathology, Hô
  • Marie PY; From the Inserm UMR_S1116 (A.B., J.L., M.D., Y.B., S.G.) and School of Surgery (N. T., F. G.), Faculté de Médecine de Nancy, Université de Lorraine, Nancy, France; Medical Intensive Care Unit, Hôpital Central (J.L., S.G.), Nancyclotep, Hôpital Brabois (F.M., P.-Y.M.), and Department of Pathology, Hô
  • Cohen R; From the Inserm UMR_S1116 (A.B., J.L., M.D., Y.B., S.G.) and School of Surgery (N. T., F. G.), Faculté de Médecine de Nancy, Université de Lorraine, Nancy, France; Medical Intensive Care Unit, Hôpital Central (J.L., S.G.), Nancyclotep, Hôpital Brabois (F.M., P.-Y.M.), and Department of Pathology, Hô
  • Danchin N; From the Inserm UMR_S1116 (A.B., J.L., M.D., Y.B., S.G.) and School of Surgery (N. T., F. G.), Faculté de Médecine de Nancy, Université de Lorraine, Nancy, France; Medical Intensive Care Unit, Hôpital Central (J.L., S.G.), Nancyclotep, Hôpital Brabois (F.M., P.-Y.M.), and Department of Pathology, Hô
  • Silvestre JS; From the Inserm UMR_S1116 (A.B., J.L., M.D., Y.B., S.G.) and School of Surgery (N. T., F. G.), Faculté de Médecine de Nancy, Université de Lorraine, Nancy, France; Medical Intensive Care Unit, Hôpital Central (J.L., S.G.), Nancyclotep, Hôpital Brabois (F.M., P.-Y.M.), and Department of Pathology, Hô
  • Ait-Oufella H; From the Inserm UMR_S1116 (A.B., J.L., M.D., Y.B., S.G.) and School of Surgery (N. T., F. G.), Faculté de Médecine de Nancy, Université de Lorraine, Nancy, France; Medical Intensive Care Unit, Hôpital Central (J.L., S.G.), Nancyclotep, Hôpital Brabois (F.M., P.-Y.M.), and Department of Pathology, Hô
  • Gibot S; From the Inserm UMR_S1116 (A.B., J.L., M.D., Y.B., S.G.) and School of Surgery (N. T., F. G.), Faculté de Médecine de Nancy, Université de Lorraine, Nancy, France; Medical Intensive Care Unit, Hôpital Central (J.L., S.G.), Nancyclotep, Hôpital Brabois (F.M., P.-Y.M.), and Department of Pathology, Hô
Circ Res ; 116(11): 1772-82, 2015 May 22.
Article em En | MEDLINE | ID: mdl-25840803
ABSTRACT
RATIONALE Optimal outcome after myocardial infarction (MI) depends on a coordinated healing response in which both debris removal and repair of the myocardial extracellular matrix play a major role. However, adverse remodeling and excessive inflammation can promote heart failure, positioning leucocytes as central protagonists and potential therapeutic targets in tissue repair and wound healing after MI.

OBJECTIVE:

In this study, we examined the role of triggering receptor expressed on myeloid cells-1(TREM-1) in orchestrating the inflammatory response that follows MI. TREM-1, expressed by neutrophils and mature monocytes, is an amplifier of the innate immune response. METHODS AND

RESULTS:

After infarction, TREM-1 expression is upregulated in ischemic myocardium in mice and humans. Trem-1 genetic invalidation or pharmacological inhibition using a synthetic peptide (LR12) dampens myocardial inflammation, limits neutrophils recruitment and monocyte chemoattractant protein-1 production, thus reducing classical monocytes mobilization to the heart. It also improves left ventricular function and survival in mice (n=20-22 per group). During both permanent and transient myocardial ischemia, Trem-1 blockade also ameliorates cardiac function and limits ventricular remodeling as assessed by fluorodeoxyglucose-positron emission tomographic imaging and conductance catheter studies (n=9-18 per group). The soluble form of TREM-1 (sTREM-1), a marker of TREM-1 activation, is detectable in the plasma of patients having an acute MI (n=1015), and its concentration is an independent predictor of death.

CONCLUSIONS:

These data suggest that TREM-1 could constitute a new therapeutic target during acute MI.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glicoproteínas de Membrana / Receptores Imunológicos / Inflamação / Infarto do Miocárdio Tipo de estudo: Prognostic_studies Idioma: En Revista: Circ Res Ano de publicação: 2015 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glicoproteínas de Membrana / Receptores Imunológicos / Inflamação / Infarto do Miocárdio Tipo de estudo: Prognostic_studies Idioma: En Revista: Circ Res Ano de publicação: 2015 Tipo de documento: Article