[Methodical ware for the hygienic risk assessment of vanadium exposure to the children's health].

ABSTRACT

In the article there is considered the complex of methodological approaches for the detection of vanadium in the air and biological substrates of the population for the practical use in the frameworks of public health monitoring in areas with localization of steel industry facilities. The developed complex of methods on the base of mass spectrometry with inductively coupled plasma (ICP-MS) allowed to perform the hygienic assessment of the quality of objects of the environment in the territory located in the zone of the impact of emissions of ferrovanadium production (the city of Tchusovoy of the Perm Krai). From the results of the study there was established the significant excess of the vanadium content in the ambient air of the studied area in relation to the control territory and to the reference concentration for chronic inhalation exposure (RfCxp) to 6.0 times. There was revealed a significant excess of vanadium content in the blood of children residing in the study area, with respect to the regional background levels (0.0001-0.00016 mg/dm3). Complex clinical laboratory and chemical-analytical studies of biosubstrates of the children population allowed to substantiate the marker of the inhalation exposure (the vanadium content in the blood) and its reference level (0.0023 dm3).