Obstructive heart defects associated with candidate genes, maternal obesity, and folic acid supplementation.

Tang, Xinyu; Cleves, Mario A; Nick, Todd G; Li, Ming; MacLeod, Stewart L; Erickson, Stephen W; Li, Jingyun; Shaw, Gary M; Mosley, Bridget S; Hobbs, Charlotte A

Tang, Xinyu; Cleves, Mario A; Nick, Todd G; Li, Ming; MacLeod, Stewart L; Erickson, Stephen W; Li, Jingyun; Shaw, Gary M; Mosley, Bridget S; Hobbs, Charlotte A.

Afiliação

Tang X; Biostatistics Program, Department of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
Cleves MA; Division of Birth Defects Research, Department of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
Nick TG; Biostatistics Program, Department of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
Li M; Biostatistics Program, Department of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
MacLeod SL; Division of Birth Defects Research, Department of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
Erickson SW; Department of Biostatistics, College of Public Health, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
Li J; Biostatistics Program, Department of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
Shaw GM; Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University Medical School, Palo Alto, California.
Mosley BS; Division of Birth Defects Research, Department of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
Hobbs CA; Division of Birth Defects Research, Department of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas.

Am J Med Genet A ; 167(6): 1231-42, 2015 Jun.

Article em En | MEDLINE | ID: mdl-25846410

Assuntos

Betaína-Homocisteína S-Metiltransferase/genética; Cardiomiopatia Hipertrófica/genética; DNA (Citosina-5-)-Metiltransferases/genética; Glutamato-Cisteína Ligase/genética; Metilenotetra-Hidrofolato Redutase (NADPH2)/genética; Obesidade/genética; Adulto; Betaína-Homocisteína S-Metiltransferase/metabolismo; Cardiomiopatia Hipertrófica/etiologia; Cardiomiopatia Hipertrófica/metabolismo; Cardiomiopatia Hipertrófica/patologia; DNA (Citosina-5-)-Metiltransferases/metabolismo; Suplementos Nutricionais/efeitos adversos; Feminino; Ácido Fólico/efeitos adversos; Expressão Gênica; Interação Gene-Ambiente; Glutamato-Cisteína Ligase/metabolismo; Glutationa/metabolismo; Homocisteína/metabolismo; Humanos; Lactente; Metilenotetra-Hidrofolato Redutase (NADPH2)/metabolismo; Modelos Genéticos; Obesidade/etiologia; Obesidade/metabolismo; Obesidade/patologia; Polimorfismo de Nucleotídeo Único; Gravidez; Fatores de Risco; DNA Metiltransferase 3B

Palavras-chave

congenital heart defects; folic acid supplementation; genetic variants; hybrid design; maternal obesity; obstructive heart defects

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cardiomiopatia Hipertrófica / Metilenotetra-Hidrofolato Redutase (NADPH2) / DNA (Citosina-5-)-Metiltransferases / Betaína-Homocisteína S-Metiltransferase / Glutamato-Cisteína Ligase / Obesidade Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Infant / Pregnancy Idioma: En Revista: Am J Med Genet A Assunto da revista: GENETICA MEDICA Ano de publicação: 2015 Tipo de documento: Article

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