Extension of the Dermal Sensitisation Threshold (DST) approach to incorporate chemicals classified as reactive.

Safford, Robert J; Api, Anne Marie; Roberts, David W; Lalko, Jon F

Safford, Robert J; Api, Anne Marie; Roberts, David W; Lalko, Jon F.

Afiliação

Safford RJ; B-Safe Toxicology Consulting, 31 Hayway, Rushden, Northants NN10 6AG, United Kingdom. Electronic address: bob.safford@bstoxconsult.co.uk.
Api AM; Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, United States. Electronic address: amapi@rifm.org.
Roberts DW; School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Byrom Street, Liverpool L3 3AF, United Kingdom. Electronic address: d.w.roberts@ljmu.ac.uk.
Lalko JF; Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, United States. Electronic address: jlalko@rifm.org.

Regul Toxicol Pharmacol ; 72(3): 694-701, 2015 Aug.

Article em En | MEDLINE | ID: mdl-25934255

Assuntos

Alérgenos/toxicidade; Dermatite Alérgica de Contato/etnologia; Medição de Risco/métodos; Animais; Bioensaio; Bases de Dados Factuais; Relação Dose-Resposta a Droga; Humanos; Linfonodos/imunologia; Nível de Efeito Adverso não Observado; Proteínas/metabolismo

Palavras-chave

Dermal Sensitisation Threshold (DST); Local Lymph Node Assay (LLNA); Non-animal methods; Sensitisation risk assessment; Skin sensitisation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Alérgenos / Dermatite Alérgica de Contato / Medição de Risco Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Revista: Regul Toxicol Pharmacol Ano de publicação: 2015 Tipo de documento: Article

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