C-H activation generates period-shortening molecules that target cryptochrome in the mammalian circadian clock.
Angew Chem Int Ed Engl
; 54(24): 7193-7, 2015 Jun 08.
Article
em En
| MEDLINE
| ID: mdl-25960183
ABSTRACT
The synthesis and functional analysis of KL001 derivatives, which are modulators of the mammalian circadian clock, are described. By using cutting-edge C-H activation chemistry, a focused library of KL001 derivatives was rapidly constructed, which enabled the identification of the critical sites on KL001 derivatives that induce a rhythm-changing activity along with the components that trigger opposite modes of action. The first period-shortening molecules that target the cryptochrome (CRY) were thus discovered. Detailed studies on the effects of these compounds on CRY stability implicate the existence of an as yet undiscovered regulatory mechanism.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sulfonamidas
/
Carbazóis
/
Ritmo Circadiano
/
Criptocromos
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Angew Chem Int Ed Engl
Ano de publicação:
2015
Tipo de documento:
Article