Lead exposure induces changes in 5-hydroxymethylcytosine clusters in CpG islands in human embryonic stem cells and umbilical cord blood.
Epigenetics
; 10(7): 607-21, 2015.
Article
em En
| MEDLINE
| ID: mdl-26046694
Palavras-chave
5-hydroxymethylcytosine; 5-methylcytosine; A-clustering approach for grouping HM450K CpG sites into clusters based on correlations; Aclust; CpG island, CpG islands are usually in the promoter and 5' untranslated regions of genes; CpG islands; CpG, sites, CG dinucleotide methylation site in the genome corresponding with probes on HM450K; DMRs, Differentially methylated regions (clusters) identified by GEE; DhMRs, Differentially Hydroxymethylated regions (clusters) identified by GEE; ELEMENT, Early Life Exposure in Mexico to Environmental Toxicants; GEE, Generalized Estimating Equations, used to measure the estimated change in DNA methylation in co-regulated regions of the genome; HM450K; HM450K, Infinium Human Methylation 450K BeadChip array from Illumina; HMeDIP-450K; HMeDIP-450K, Infinium Human Methylation 450K BeadChip array from Illumina coupled with immunoprecipitation with 5hmC antibodies; LINE-1, Long Interspersed Element 1, a common retrotransposon in humans; MRs, Methylation regions (clusters) identified by A-clustering; clusters; hMRs, Hydroxymethylated regions (clusters) identified by A-clustering; lead; umbilical cord blood
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cordão Umbilical
/
Ilhas de CpG
/
Citosina
/
Exposição Ambiental
/
Células-Tronco Embrionárias Humanas
/
Chumbo
Tipo de estudo:
Prognostic_studies
Limite:
Humans
País/Região como assunto:
Mexico
Idioma:
En
Revista:
Epigenetics
Assunto da revista:
GENETICA
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Estados Unidos