Immunology of a Transmissible Cancer Spreading among Tasmanian Devils.
J Immunol
; 195(1): 23-9, 2015 Jul 01.
Article
em En
| MEDLINE
| ID: mdl-26092814
ABSTRACT
Devil facial tumor disease (DFTD) is a transmissible cancer that has killed most of the Tasmanian devil (Sarcophilus harrissii) population. Since the first case appeared in the mid-1990s, it has spread relentlessly across the Tasmanian devil's geographic range. As Tasmanian devils only exist in Tasmania, Australia, DFTD has the potential to cause extinction of this species. The origin of DFTD was a Schwann cell from a female devil. The disease is transmitted when devils bite each other around the facial areas, a behavior synonymous with this species. Every devil that is 'infected' with DFTD dies from the cancer. Once the DFTD cells have been transmitted, they appear to develop into a cancer without inducing an immune response. The DFTD cancer cells avoid allogeneic recognition because they do not express MHC class I molecules on the cell surface. A reduced genetic diversity and the production of immunosuppressive cytokines may also contribute.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células de Schwann
/
Mordeduras e Picadas
/
Neoplasias Faciais
/
Transmissão de Doença Infecciosa
/
Marsupiais
Tipo de estudo:
Prognostic_studies
Limite:
Animals
País/Região como assunto:
Oceania
Idioma:
En
Revista:
J Immunol
Ano de publicação:
2015
Tipo de documento:
Article