Selective decontamination and antibiotic resistance in ICUs.
Crit Care
; 19: 259, 2015 Jun 24.
Article
em En
| MEDLINE
| ID: mdl-26104045
ABSTRACT
Selective digestive decontamination (SDD) and selective oropharyngeal decontamination (SOD) have been associated with reduced mortality and lower ICU-acquired bacteremia and ventilator-associated pneumonia rates in areas with low levels of antibiotic resistance. However, the effect of selective decontamination (SDD/SOD) in areas where multidrug-resistant Gram-negative bacteria are endemic is less clear. It will be important to determine whether SDD/SOD improves patient outcome in such settings and how these measures affect the epidemiology of multidrug-resistant Gram-negative bacteria. Here we review the current evidence on the effects of SDD/SOD on antibiotic resistance development in individual ICU patients as well as the effect on ICU ecology, the latter including both ICU-level antibiotic resistance and antibiotic resistance development during long-term use of SDD/SOD.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Portador Sadio
/
Bacteriemia
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Farmacorresistência Bacteriana
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Pneumonia Associada à Ventilação Mecânica
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Unidades de Terapia Intensiva
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Antibacterianos
Limite:
Humans
Idioma:
En
Revista:
Crit Care
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Holanda