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The VA augmentation and switching treatments for improving depression outcomes (VAST-D) study: Rationale and design considerations.
Mohamed, Somaia; Johnson, Gary R; Vertrees, Julia E; Guarino, Peter D; Weingart, Kimberly; Young, Ilanit Tal; Yoon, Jean; Gleason, Theresa C; Kirkwood, Katherine A; Kilbourne, Amy M; Gerrity, Martha; Marder, Stephen; Biswas, Kousick; Hicks, Paul; Davis, Lori L; Chen, Peijun; Kelada, AlexandraMary; Huang, Grant D; Lawrence, David D; LeGwin, Mary; Zisook, Sidney.
Afiliação
  • Mohamed S; VA VISN 1 New England Mental Illness Research,Education and Clinical Center, Veterans Health Administration, West Haven, CT and Yale University School of Medicine, 950 Campbell Ave., West Haven, CT 06516, USA. Electronic address: Somaia.Mohamed@va.gov.
  • Johnson GR; VA Cooperative Studies Program Coordinating Center, VA Connecticut Healthcare System, West Haven, CT, USA.
  • Vertrees JE; VA Cooperative Studies Program Clinical Research Pharmacy Coordinating Center, New Mexico VA Healthcare System, Albuquerque, NM, USA.
  • Guarino PD; VA Cooperative Studies Program Coordinating Center, VA Connecticut Healthcare System, West Haven, CT, USA; Statistical Center for HIV/AIDS Research and Prevention, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
  • Weingart K; VA San Diego Healthcare System and University of California, San Diego, CA, USA.
  • Young IT; VA San Diego Healthcare System and University of California, San Diego, CA, USA.
  • Yoon J; Health Economics Resource Center (HERC), VA Palo Alto, Menlo Park, CA, USA.
  • Gleason TC; Department of Veterans Affairs, Office of Research and Development, Washington, DC, USA.
  • Kirkwood KA; VA Cooperative Studies Program Coordinating Center, VA Connecticut Healthcare System, West Haven, CT, USA.
  • Kilbourne AM; Department of Veterans Affairs, Office of Research and Development, Washington, DC, USA; Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
  • Gerrity M; Portland VA Healthcare System, Portland, OR, USA.
  • Marder S; VA Desert Pacific Mental Illness Research, Education, and Clinical Center and Semel Institute for Neuroscience at UCLA, Los Angeles, CA, USA.
  • Biswas K; VA Cooperative Studies Program Coordinating Center, VA Maryland Healthcare Systems, Perry Point, MD, USA.
  • Hicks P; Central Texas Veterans Healthcare System and Department of Psychiatry and Behavioral Science, Texas A&M Health Science Center College of Medicine, Temple, TX, USA.
  • Davis LL; Tuscaloosa VA Medical Center, Tuscaloosa, AL and University of Alabama School of Medicine, USA.
  • Chen P; Louis Stokes VA Medical Center and Case Western Reserve University School of Medicine, Cleveland, OH, USA.
  • Kelada A; VA San Diego Healthcare System and University of California, San Diego, CA, USA.
  • Huang GD; Cooperative Studies Program Central Office, Department of Veterans Affairs Office of Research & Development, Washington, DC, USA.
  • Lawrence DD; VA Cooperative Studies Program Coordinating Center, VA Connecticut Healthcare System, West Haven, CT, USA.
  • LeGwin M; VA Cooperative Studies Program Coordinating Center, VA Connecticut Healthcare System, West Haven, CT, USA.
  • Zisook S; VA San Diego Healthcare System and University of California, San Diego, CA, USA.
Psychiatry Res ; 229(3): 760-70, 2015 Oct 30.
Article em En | MEDLINE | ID: mdl-26279130
ABSTRACT
Because two-thirds of patients with Major Depressive Disorder do not achieve remission with their first antidepressant, we designed a trial of three "next-step" strategies switching to another antidepressant (bupropion-SR) or augmenting the current antidepressant with either another antidepressant (bupropion-SR) or with an atypical antipsychotic (aripiprazole). The study will compare 12-week remission rates and, among those who have at least a partial response, relapse rates for up to 6 months of additional treatment. We review seven key efficacy/effectiveness design decisions in this mixed "efficacy-effectiveness" trial.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Projetos de Pesquisa / Antipsicóticos / Indução de Remissão / Transtorno Depressivo Maior / Substituição de Medicamentos / Antidepressivos Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Female / Humans / Male Idioma: En Revista: Psychiatry Res Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Projetos de Pesquisa / Antipsicóticos / Indução de Remissão / Transtorno Depressivo Maior / Substituição de Medicamentos / Antidepressivos Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Female / Humans / Male Idioma: En Revista: Psychiatry Res Ano de publicação: 2015 Tipo de documento: Article