18F-Labeled Single-Stranded DNA Aptamer for PET Imaging of Protein Tyrosine Kinase-7 Expression.

Jacobson, Orit; Weiss, Ido D; Wang, Lu; Wang, Zhe; Yang, Xiangyu; Dewhurst, Andrew; Ma, Ying; Zhu, Guizhi; Niu, Gang; Kiesewetter, Dale O; Vasdev, Neil; Liang, Steven H; Chen, Xiaoyuan

Jacobson, Orit; Weiss, Ido D; Wang, Lu; Wang, Zhe; Yang, Xiangyu; Dewhurst, Andrew; Ma, Ying; Zhu, Guizhi; Niu, Gang; Kiesewetter, Dale O; Vasdev, Neil; Liang, Steven H; Chen, Xiaoyuan.

Afiliação

Jacobson O; Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering.
Weiss ID; Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases; National Institutes of Health, Bethesda, MD, USA.
Wang L; Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital & Department of Radiology, Harvard Medical School, Boston, MA, USA.
Wang Z; Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering.
Yang X; Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering.
Dewhurst A; Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering.
Ma Y; Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering.
Zhu G; Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering.
Niu G; Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering.
Kiesewetter DO; Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering.
Vasdev N; Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital & Department of Radiology, Harvard Medical School, Boston, MA, USA.
Liang SH; Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital & Department of Radiology, Harvard Medical School, Boston, MA, USA.
Chen X; Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering.

J Nucl Med ; 56(11): 1780-1785, 2015 Nov.

Article em En | MEDLINE | ID: mdl-26315836

Assuntos

Aptâmeros de Nucleotídeos/química; Moléculas de Adesão Celular/biossíntese; DNA de Cadeia Simples/genética; Compostos Radiofarmacêuticos/química; Receptores Proteína Tirosina Quinases/biossíntese; Animais; Moléculas de Adesão Celular/genética; Linhagem Celular Tumoral; Radioisótopos de Flúor; Regulação Enzimológica da Expressão Gênica/genética; Humanos; Marcação por Isótopo; Camundongos; Neoplasias Experimentais/diagnóstico por imagem; Tomografia por Emissão de Pósitrons; Receptores Proteína Tirosina Quinases/genética; Distribuição Tecidual; Tomografia Computadorizada de Emissão de Fóton Único; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

18F; PET imaging; PTK7; click chemistry; ssDNA aptamer

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: DNA de Cadeia Simples / Moléculas de Adesão Celular / Receptores Proteína Tirosina Quinases / Compostos Radiofarmacêuticos / Aptâmeros de Nucleotídeos Limite: Animals / Humans Idioma: En Revista: J Nucl Med Ano de publicação: 2015 Tipo de documento: Article

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