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Hallmarks of pluripotency.
De Los Angeles, Alejandro; Ferrari, Francesco; Xi, Ruibin; Fujiwara, Yuko; Benvenisty, Nissim; Deng, Hongkui; Hochedlinger, Konrad; Jaenisch, Rudolf; Lee, Soohyun; Leitch, Harry G; Lensch, M William; Lujan, Ernesto; Pei, Duanqing; Rossant, Janet; Wernig, Marius; Park, Peter J; Daley, George Q.
Afiliação
  • De Los Angeles A; Stem Cell Transplantation Program, Division of Pediatric Hematology Oncology, Children's Hospital Boston, and Dana-Farber Cancer Institute; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Ferrari F; Harvard Stem Cell Institute, Cambridge, Massachusetts 02138, USA.
  • Xi R; Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA.
  • Fujiwara Y; Department of Biomedical Informatics, Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Benvenisty N; Department of Biomedical Informatics, Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Deng H; School of Mathematical Sciences and Center for Statistical Science, Peking University, Beijing 100871, China.
  • Hochedlinger K; Stem Cell Transplantation Program, Division of Pediatric Hematology Oncology, Children's Hospital Boston, and Dana-Farber Cancer Institute; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Jaenisch R; Harvard Stem Cell Institute, Cambridge, Massachusetts 02138, USA.
  • Lee S; Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA.
  • Leitch HG; Stem Cell Unit, Department of Genetics, Institute of Life Sciences, The Hebrew University, Jerusalem 91904, Israel.
  • Lensch MW; College of Life Sciences and Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China.
  • Lujan E; Harvard Stem Cell Institute, Cambridge, Massachusetts 02138, USA.
  • Pei D; Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA.
  • Rossant J; Department of Biomedical Informatics, Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Wernig M; Massachusetts General Hospital Cancer Center and Center for Regenerative Medicine, Boston, Massachusetts 02114, USA.
  • Park PJ; Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA.
  • Daley GQ; Department of Biomedical Informatics, Harvard Medical School, Boston, Massachusetts 02115, USA.
Nature ; 525(7570): 469-78, 2015 Sep 24.
Article em En | MEDLINE | ID: mdl-26399828
ABSTRACT
Stem cells self-renew and generate specialized progeny through differentiation, but vary in the range of cells and tissues they generate, a property called developmental potency. Pluripotent stem cells produce all cells of an organism, while multipotent or unipotent stem cells regenerate only specific lineages or tissues. Defining stem-cell potency relies upon functional assays and diagnostic transcriptional, epigenetic and metabolic states. Here we describe functional and molecular hallmarks of pluripotent stem cells, propose a checklist for their evaluation, and illustrate how forensic genomics can validate their provenance.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células-Tronco Pluripotentes Limite: Animals / Humans Idioma: En Revista: Nature Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células-Tronco Pluripotentes Limite: Animals / Humans Idioma: En Revista: Nature Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos