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CRISPR/Cas9 somatic multiplex-mutagenesis for high-throughput functional cancer genomics in mice.
Weber, Julia; Öllinger, Rupert; Friedrich, Mathias; Ehmer, Ursula; Barenboim, Maxim; Steiger, Katja; Heid, Irina; Mueller, Sebastian; Maresch, Roman; Engleitner, Thomas; Gross, Nina; Geumann, Ulf; Fu, Beiyuan; Segler, Angela; Yuan, Detian; Lange, Sebastian; Strong, Alexander; de la Rosa, Jorge; Esposito, Irene; Liu, Pentao; Cadiñanos, Juan; Vassiliou, George S; Schmid, Roland M; Schneider, Günter; Unger, Kristian; Yang, Fengtang; Braren, Rickmer; Heikenwälder, Mathias; Varela, Ignacio; Saur, Dieter; Bradley, Allan; Rad, Roland.
Afiliação
  • Weber J; Department of Medicine II, Klinikum Rechts der Isar, Technische Universität München, 81675 Munich, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany;
  • Öllinger R; Department of Medicine II, Klinikum Rechts der Isar, Technische Universität München, 81675 Munich, Germany;
  • Friedrich M; The Wellcome Trust Sanger Institute, CB10 1SA Hinxton/Cambridge, United Kingdom;
  • Ehmer U; Department of Medicine II, Klinikum Rechts der Isar, Technische Universität München, 81675 Munich, Germany;
  • Barenboim M; Department of Medicine II, Klinikum Rechts der Isar, Technische Universität München, 81675 Munich, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany;
  • Steiger K; Department of Pathology, Klinikum Rechts der Isar, Technische Universität München, 81675 Munich, Germany;
  • Heid I; Institute of Radiology, Klinikum Rechts der Isar, Technische Universität München, 81675 Munich, Germany;
  • Mueller S; Department of Medicine II, Klinikum Rechts der Isar, Technische Universität München, 81675 Munich, Germany;
  • Maresch R; Department of Medicine II, Klinikum Rechts der Isar, Technische Universität München, 81675 Munich, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany;
  • Engleitner T; Department of Medicine II, Klinikum Rechts der Isar, Technische Universität München, 81675 Munich, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany;
  • Gross N; Department of Medicine II, Klinikum Rechts der Isar, Technische Universität München, 81675 Munich, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany;
  • Geumann U; Department of Medicine II, Klinikum Rechts der Isar, Technische Universität München, 81675 Munich, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany;
  • Fu B; The Wellcome Trust Sanger Institute, CB10 1SA Hinxton/Cambridge, United Kingdom;
  • Segler A; Department of Pathology, Klinikum Rechts der Isar, Technische Universität München, 81675 Munich, Germany;
  • Yuan D; Institute of Virology, Technische Universität München and Helmholtz Zentrum München, 81675 Munich, Germany;
  • Lange S; Department of Medicine II, Klinikum Rechts der Isar, Technische Universität München, 81675 Munich, Germany;
  • Strong A; The Wellcome Trust Sanger Institute, CB10 1SA Hinxton/Cambridge, United Kingdom;
  • de la Rosa J; The Wellcome Trust Sanger Institute, CB10 1SA Hinxton/Cambridge, United Kingdom;
  • Esposito I; Institute of Pathology, Heinrich-Heine-University Düsseldorf, 40225 Düsseldorf, Germany;
  • Liu P; The Wellcome Trust Sanger Institute, CB10 1SA Hinxton/Cambridge, United Kingdom;
  • Cadiñanos J; Instituto de Medicina Oncológica y Molecular de Asturias, 33193 Oviedo, Spain;
  • Vassiliou GS; The Wellcome Trust Sanger Institute, CB10 1SA Hinxton/Cambridge, United Kingdom;
  • Schmid RM; Department of Medicine II, Klinikum Rechts der Isar, Technische Universität München, 81675 Munich, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany;
  • Schneider G; Department of Medicine II, Klinikum Rechts der Isar, Technische Universität München, 81675 Munich, Germany;
  • Unger K; Research Unit Radiation Cytogenetics, Helmholtz Zentrum München, 85764 Neuherberg, Germany;
  • Yang F; The Wellcome Trust Sanger Institute, CB10 1SA Hinxton/Cambridge, United Kingdom;
  • Braren R; Institute of Radiology, Klinikum Rechts der Isar, Technische Universität München, 81675 Munich, Germany;
  • Heikenwälder M; Institute of Virology, Technische Universität München and Helmholtz Zentrum München, 81675 Munich, Germany; Division of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany;
  • Varela I; Instituto de Biomedicina y Biotecnología de Cantabria, 39011 Santander, Spain.
  • Saur D; Department of Medicine II, Klinikum Rechts der Isar, Technische Universität München, 81675 Munich, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany;
  • Bradley A; The Wellcome Trust Sanger Institute, CB10 1SA Hinxton/Cambridge, United Kingdom;
  • Rad R; Department of Medicine II, Klinikum Rechts der Isar, Technische Universität München, 81675 Munich, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; roland.rad@tum.de.
Proc Natl Acad Sci U S A ; 112(45): 13982-7, 2015 Nov 10.
Article em En | MEDLINE | ID: mdl-26508638
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Mutagênese / Carcinoma Hepatocelular / Genômica / Modelos Animais de Doenças / Ensaios de Triagem em Larga Escala / Sistemas CRISPR-Cas / Neoplasias Hepáticas Limite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2015 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Mutagênese / Carcinoma Hepatocelular / Genômica / Modelos Animais de Doenças / Ensaios de Triagem em Larga Escala / Sistemas CRISPR-Cas / Neoplasias Hepáticas Limite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2015 Tipo de documento: Article