Novel antibody-antibiotic conjugate eliminates intracellular S. aureus.
Nature
; 527(7578): 323-8, 2015 Nov 19.
Article
em En
| MEDLINE
| ID: mdl-26536114
ABSTRACT
Staphylococcus aureus is considered to be an extracellular pathogen. However, survival of S. aureus within host cells may provide a reservoir relatively protected from antibiotics, thus enabling long-term colonization of the host and explaining clinical failures and relapses after antibiotic therapy. Here we confirm that intracellular reservoirs of S. aureus in mice comprise a virulent subset of bacteria that can establish infection even in the presence of vancomycin, and we introduce a novel therapeutic that effectively kills intracellular S. aureus. This antibody-antibiotic conjugate consists of an anti-S. aureus antibody conjugated to a highly efficacious antibiotic that is activated only after it is released in the proteolytic environment of the phagolysosome. The antibody-antibiotic conjugate is superior to vancomycin for treatment of bacteraemia and provides direct evidence that intracellular S. aureus represents an important component of invasive infections.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Infecções Estafilocócicas
/
Staphylococcus aureus
/
Vancomicina
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Bacteriemia
/
Imunoconjugados
/
Espaço Intracelular
/
Antibacterianos
Limite:
Animals
Idioma:
En
Revista:
Nature
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Estados Unidos