Replication stress induced site-specific phosphorylation targets WRN to the ubiquitin-proteasome pathway.

Su, Fengtao; Bhattacharya, Souparno; Abdisalaam, Salim; Mukherjee, Shibani; Yajima, Hirohiko; Yang, Yanyong; Mishra, Ritu; Srinivasan, Kalayarasan; Ghose, Subroto; Chen, David J; Yannone, Steven M; Asaithamby, Aroumougame

Su, Fengtao; Bhattacharya, Souparno; Abdisalaam, Salim; Mukherjee, Shibani; Yajima, Hirohiko; Yang, Yanyong; Mishra, Ritu; Srinivasan, Kalayarasan; Ghose, Subroto; Chen, David J; Yannone, Steven M; Asaithamby, Aroumougame.

Afiliação

Su F; Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Bhattacharya S; Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Abdisalaam S; Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Mukherjee S; Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Yajima H; Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Yang Y; Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan.
Mishra R; Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Srinivasan K; Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Ghose S; Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Chen DJ; Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Yannone SM; Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Asaithamby A; Life Science Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA.

Oncotarget ; 7(1): 46-65, 2016 Jan 05.

Article em En | MEDLINE | ID: mdl-26695548

Assuntos

Replicação do DNA; Exodesoxirribonucleases/metabolismo; Complexo de Endopeptidases do Proteassoma/metabolismo; RecQ Helicases/metabolismo; Transdução de Sinais; Ubiquitinas/metabolismo; Proteínas Mutadas de Ataxia Telangiectasia/genética; Proteínas Mutadas de Ataxia Telangiectasia/metabolismo; Sítios de Ligação/genética; Western Blotting; Linhagem Celular Tumoral; Células Cultivadas; Dano ao DNA; Reparo do DNA; Exodesoxirribonucleases/genética; Recuperação de Fluorescência Após Fotodegradação; Células HeLa; Humanos; Microscopia Confocal; Fosforilação; RecQ Helicases/genética; Serina/genética; Serina/metabolismo; Helicase da Síndrome de Werner

Palavras-chave

Gerotarget; Werner syndrome; Werner syndrome protein; chromosome instability; post-translational modification; replication stress

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ubiquitinas / Transdução de Sinais / Complexo de Endopeptidases do Proteassoma / Replicação do DNA / Exodesoxirribonucleases / RecQ Helicases Limite: Humans Idioma: En Revista: Oncotarget Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos

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