Constitutive active/androstane receptor, peroxisome proliferator-activated receptor &#945;, and cytotoxicity are involved in oxadiazon-induced liver tumor development in mice.

Kuwata, Kazunori; Inoue, Kaoru; Ichimura, Ryohei; Takahashi, Miwa; Kodama, Yukio; Yoshida, Midori

Constitutive active/androstane receptor, peroxisome proliferator-activated receptor α, and cytotoxicity are involved in oxadiazon-induced liver tumor development in mice.

Kuwata, Kazunori; Inoue, Kaoru; Ichimura, Ryohei; Takahashi, Miwa; Kodama, Yukio; Yoshida, Midori.

Afiliação

Kuwata K; Division of Pathology, National Institute of Health Sciences, Kamiyoga 1-18-1, Setagaya-ku, Tokyo 158-8501, Japan; Safety Research Laboratories, Sohyaku. Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, 1-1-1, Kazusakamatari, Kisarazu, Chiba 292-0818, Japan; Laboratory of Veterina
Inoue K; Division of Pathology, National Institute of Health Sciences, Kamiyoga 1-18-1, Setagaya-ku, Tokyo 158-8501, Japan.
Ichimura R; Division of Pathology, National Institute of Health Sciences, Kamiyoga 1-18-1, Setagaya-ku, Tokyo 158-8501, Japan.
Takahashi M; Division of Pathology, National Institute of Health Sciences, Kamiyoga 1-18-1, Setagaya-ku, Tokyo 158-8501, Japan.
Kodama Y; Division of Toxicology, National Institute of Health Sciences, Kamiyoga 1-18-1, Setagaya-ku, Tokyo 158-8501, Japan.
Yoshida M; Division of Pathology, National Institute of Health Sciences, Kamiyoga 1-18-1, Setagaya-ku, Tokyo 158-8501, Japan; Food Safety Commission, Cabinet Office, Akasaka Park Bld 22F, 5-2-20 Akasaka, Minato-ku, Tokyo 107-6122, Japan. Electronic address: midori.yoshida@cao.go.jp.

Food Chem Toxicol ; 88: 75-86, 2016 Feb.

Article em En | MEDLINE | ID: mdl-26710982

Assuntos

Neoplasias Hepáticas/induzido quimicamente; Oxidiazóis/toxicidade; PPAR alfa/metabolismo; Receptores Citoplasmáticos e Nucleares/metabolismo; Animais; Carcinogênese/induzido quimicamente; Morte Celular; Células Cultivadas; Receptor Constitutivo de Androstano; Hepatócitos/efeitos dos fármacos; Herbicidas/toxicidade; Masculino; Camundongos; PPAR alfa/genética; Receptores Citoplasmáticos e Nucleares/genética

Palavras-chave

CAR; Liver tumorigenesis; Mice; Oxadiazon; Porphyrin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oxidiazóis / Receptores Citoplasmáticos e Nucleares / PPAR alfa / Neoplasias Hepáticas Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Revista: Food Chem Toxicol Ano de publicação: 2016 Tipo de documento: Article

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