LC-MS/MS-Based Monitoring of In Vivo Protein Biotransformation: Quantitative Determination of Trastuzumab and Its Deamidation Products in Human Plasma.

Bults, Peter; Bischoff, Rainer; Bakker, Hilde; Gietema, Jourik A; van de Merbel, Nico C

Bults, Peter; Bischoff, Rainer; Bakker, Hilde; Gietema, Jourik A; van de Merbel, Nico C.

Afiliação

Bults P; Bioanalytical Laboratory, PRA Health Sciences, Early Development Services, Amerikaweg 18, 9407 TK Assen, The Netherlands.
Bischoff R; Analytical Biochemistry, Department of Pharmacy, University of Groningen , A. Deusinglaan 1, 9700 AV Groningen, The Netherlands.
Bakker H; Analytical Biochemistry, Department of Pharmacy, University of Groningen , A. Deusinglaan 1, 9700 AV Groningen, The Netherlands.
Gietema JA; Bioanalytical Laboratory, PRA Health Sciences, Early Development Services, Amerikaweg 18, 9407 TK Assen, The Netherlands.
van de Merbel NC; Faculty of Medical Sciences, Department of Medical Oncology, University Medical Centre Groningen , Hanzeplein 1, 9713 GZ Groningen, The Netherlands.

Anal Chem ; 88(3): 1871-7, 2016 Feb 02.

Article em En | MEDLINE | ID: mdl-26713683

Assuntos

Succinimidas/sangue; Trastuzumab/sangue; Biotransformação; Cromatografia Líquida de Alta Pressão; Estrutura Molecular; Succinimidas/metabolismo; Espectrometria de Massas em Tandem; Trastuzumab/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Succinimidas / Trastuzumab Tipo de estudo: Guideline Idioma: En Revista: Anal Chem Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Holanda

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