GPCR profiling: from hits to leads and from genotype to phenotype.
Drug Discov Today Technol
; 18: 30-7, 2015 Nov.
Article
em En
| MEDLINE
| ID: mdl-26723890
ABSTRACT
GPCRs remain one of the most important classes of drug targets and, therefore, GPCR assay development and high-throughput GPCR ligand profiling continue to be major efforts in drug discovery. This article focuses on GPCR platform strategies from hits to leads with miniaturized complex pharmacology approaches. Three main areas of GPCR profiling are discussed including pharmacologically relevant hit identification, the pharmacology dossier applied to parallel structure activity and structure liability relationships and high-throughput mechanism studies from genotype to phenotype.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Receptores Acoplados a Proteínas G
/
Bibliotecas de Moléculas Pequenas
/
Descoberta de Drogas
/
Ensaios de Triagem em Larga Escala
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Drug Discov Today Technol
Ano de publicação:
2015
Tipo de documento:
Article