[Chemical Constituents from Leaves of Hibiscus syriacus and Their α-Glucosidase Inhibitory Activities].
Zhong Yao Cai
; 38(5): 975-9, 2015 May.
Article
em Zh
| MEDLINE
| ID: mdl-26767290
ABSTRACT
OBJECTIVE:
To study the chemical constituents from Hibiscus syriacus leaves and their α-glucosidase inhibitory activities.METHODS:
Column chromatography including macroporous resins, silica gel and Sephadex LH-20 were used for the isolation and purification of all compounds. Spectroscopic methods including physical and chemical properties, 1H-NMR and 13C-NMR were used for the identification of structures. Their α-glucosidase inhibitory activities were detected by a 96-well microplate.RESULTS:
15 compounds were isolated and identified as ß-sitosterol(1), ß-daucostero (2), ß-amyrin (3), oleanolic acid (4), stigmast-4-en-3-one (5), friedelin (6), syriacusin A (7), kaempferol (8), isovitexin (9), vitexin (10), apigenin (11), apigenin-7-O-ß-D-glucopyranoside (12), luteolin-7-O-ß-D-glucopyranoside (13), vitexin-7-O-ß-D-glucopyranoside (14) and rutin (15).CONCLUSION:
All the compounds are isolated from the leaves of Hibiscus syriacus for the first time. Taking acarbose as positive control, the α-glucosidase inhibitory activities of 15 compounds were evaluated. Compounds 7 and 9 have shown strong α-glucosidase inhibitory activities with IC50 of 39.03 ± 0.38 and 32.12 ± 0.62 mg/L, inhibition ratio of 94.95% and 97.15%, respectively.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Folhas de Planta
/
Hibiscus
/
Compostos Fitoquímicos
/
Inibidores de Glicosídeo Hidrolases
Idioma:
Zh
Revista:
Zhong Yao Cai
Assunto da revista:
TERAPIAS COMPLEMENTARES
Ano de publicação:
2015
Tipo de documento:
Article