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Clinical outcomes in octogenarians treated with docetaxel as first-line chemotherapy for castration-resistant prostate cancer.
Veccia, Antonello; Caffo, Orazio; De Giorgi, Ugo; Di Lorenzo, Giuseppe; Ortega, Cinzia; Scognamiglio, Florinda; Aieta, Michele; Facchini, Gaetano; Mansueto, Giovanni; Mattioli, Rodolfo; Procopio, Giuseppe; Zagonel, Vittorina; D'Angelo, Alessandro; Spizzo, Gilbert; Bortolus, Roberto; Donini, Maddalena; Lo Re, Giovanni; Massari, Francesco; Vicario, Giovanni; Zucali, Paolo A; Alesini, Daniele; Bonetti, Andrea; Mucciarini, Claudia; Nicodemo, Maurizio; Berruti, Alfredo; Fratino, Lucia; Lodde, Michele; Messina, Caterina; Perin, Alessandra; Santini, Daniele; Sava, Teodoro; Tucci, Marcello; Basso, Umberto; Maines, Francesca; Burgio, Luca S; Galligioni, Enzo.
Afiliação
  • Veccia A; Medical Oncology Department, Santa Chiara Hospital, Largo Medaglie d'Oro, 38100 Trento, Italy.
  • Caffo O; Medical Oncology Department, Santa Chiara Hospital, Largo Medaglie d'Oro, 38100 Trento, Italy.
  • De Giorgi U; Medical Oncology Department, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Via Piero Maroncelli 40, 47014 Meldola, Italy.
  • Di Lorenzo G; Oncologia Urologica, Azienda Ospedaliera Universitaria "Federico II", Via S. Pansini 5, 80131 Napoli, Italy.
  • Ortega C; Medical Oncology Department, Institute for Cancer Research & Treatment, Strada Provinciale 142, Km 3.95, 10060 Candiolo, Italy.
  • Scognamiglio F; Medical Oncology Department, Cardarelli Hospital, Via A. Cardarelli 9, 80131 Napoli, Italy.
  • Aieta M; Medical Oncology Department, Referral Cancer Center of Basilicata - IRCCS, Via Padre Pio, 1, 85028 Rionero in Vulture, Italy.
  • Facchini G; Division of Medical Oncology, Department of Uro-Gynaecological Oncology, Istituto Nazionale Tumori "Fondazione G. Pascale" - IRCCS, Via Mariano Semmola, 80131 Naples, Italy.
  • Mansueto G; Medical Oncology Department, General Hospital, Via Fabi, 03100 Frosinone, Italy.
  • Mattioli R; Medical Oncology Department, Santa Croce Hospital, Viale Vittorio Veneto 2, 61032 Fano, Italy.
  • Procopio G; Oncologia medica genitourinaria - Fondazione Istituto Nazionale Tumori, Via Venezian 1, 20133 Milan, Italy.
  • Zagonel V; Medical Oncology Unit 1, Istituto Oncologico Veneto IOV - IRCCS, Via Gattamelata 64, 35128 Padua, Italy.
  • D'Angelo A; Medical Oncology Department, San Vincenzo Hospital, Via Sirina, 98039 Taormina, Italy.
  • Spizzo G; Medical Oncology Department, General Hospital, Via Rossini, 5, 39012 Merano, Italy.
  • Bortolus R; Radiation Oncology Department, National Cancer Institute, Via Franco Gallini, 2, 33081 Aviano, Italy.
  • Donini M; Medical Oncology Department, Istituti Ospitalieri, Viale Concordia 1, 26100 Cremona, Italy.
  • Lo Re G; Medical Oncology Department, Santa Maria degli Angeli Hospital, Via Montereale 24, 33170 Pordenone, Italy.
  • Massari F; Medical Oncology, Azienda Ospedaliera Universitaria Integrata, University of Verona, Piazzale A. Scuro 10, 37134 Verona, Italy.
  • Vicario G; Medical Oncology Department, San Giacomo Apostolo Hospital, Via dei Carpani 16/Z, 31033 Castelfranco Veneto, Italy.
  • Zucali PA; Department of Medical Oncology & Haematology, Humanitas Clinical & Research Center, Via Manzoni, 56, 20089 Rozzano, Italy.
  • Alesini D; Department of Radiological, Oncological & Anatomopathological Sciences, La Sapienza, University of Rome, Piazzale Aldo Moro, 5, 00185 Rome, Italy.
  • Bonetti A; Medical Oncology Department, Mater Salutis Hospital, Via Gianella, 1, 37045 Legnago, Italy.
  • Mucciarini C; Medical Oncology Department, Ramazzini Hospital, Via Guido Molinari, 2, 41012 Carpi, Italy.
  • Nicodemo M; Medical Oncology Department, Sacro Cuore Don Calabria Hospital, Via don A. Sempreboni, 5, 37024 Negrar, Italy.
  • Berruti A; Medical Oncology Department, Spedali Civili Hospital, P.le Spedali Civili, 1, 25123 Brescia, Italy.
  • Fratino L; Medical Oncology Department, National Cancer Institute, Via Franco Gallini, 2, 33081 Aviano, Italy.
  • Lodde M; Urology Department, General Hospital, Via Böhler 5, 39100 Bolzano, Italy.
  • Messina C; Medical Oncology Department, Papa Giovanni XXIII Hospital, Piazza OMS 1, 24127 Bergamo, Italy.
  • Perin A; Medical Oncology Department, General Hospital, via Garziere n. 42, 36014 Santorso, Italy.
  • Santini D; Medical Oncology Department, University Campus Bio-Medico, Via Álvaro del Portillo, 00128 Rome, Italy.
  • Sava T; Medical Oncology Department, General Hospital, P.le A. Stefani 1, 37126 Verona, Italy.
  • Tucci M; Medical Oncology Department, University of Torino, San Luigi Hospital, Regione Gonzole, 10, 10043 Orbassano, Italy.
  • Basso U; Medical Oncology Unit 1, Istituto Oncologico Veneto IOV - IRCCS, Via Gattamelata 64, 35128 Padua, Italy.
  • Maines F; Medical Oncology Department, Santa Chiara Hospital, Largo Medaglie d'Oro, 38100 Trento, Italy.
  • Burgio LS; Medical Oncology Department, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Via Piero Maroncelli 40, 47014 Meldola, Italy.
  • Galligioni E; Medical Oncology Department, Santa Chiara Hospital, Largo Medaglie d'Oro, 38100 Trento, Italy.
Future Oncol ; 12(4): 493-502, 2016 Feb.
Article em En | MEDLINE | ID: mdl-26776493
ABSTRACT

AIM:

To assess clinical outcomes in octogenarians treated with docetaxel (DOC) for metastatic castration-resistant prostate cancer. PATIENTS &

METHODS:

The multicenter retrospective study was based on a review of the pre- and post-DOC clinical history, DOC treatment and outcomes.

RESULTS:

We reviewed the records of 123 patients (median age 82 years) who received DOC every 3 weeks or weekly, without significant grade 3-4 toxicities. Median progression-free survival was 7 months; median overall survival from the start of DOC was 20 months, but post-progression treatments significantly prolonged overall survival.

CONCLUSION:

The findings of this study suggest that toxicity is acceptable, survival is independent of patient's age and survival can be significantly prolonged by the use of new agents.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Taxoides / Neoplasias de Próstata Resistentes à Castração / Antineoplásicos Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged80 / Humans / Male Idioma: En Revista: Future Oncol Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Itália
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Taxoides / Neoplasias de Próstata Resistentes à Castração / Antineoplásicos Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged80 / Humans / Male Idioma: En Revista: Future Oncol Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Itália