Lipidomic profiling of tryptophan hydroxylase 2 knockout mice reveals novel lipid biomarkers associated with serotonin deficiency.

Weng, Rui; Shen, Sensen; Burton, Casey; Yang, Li; Nie, Honggang; Tian, Yonglu; Bai, Yu; Liu, Huwei

Weng, Rui; Shen, Sensen; Burton, Casey; Yang, Li; Nie, Honggang; Tian, Yonglu; Bai, Yu; Liu, Huwei.

Afiliação

Weng R; Beijing National Laboratory for Molecular Sciences, the Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Institute of Analytical Chemistry, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China.
Shen S; Institute of Quality Standards and Testing Technology for Agro-Products, Chinese Academy of Agriculture Sciences, Beijing, 100081, China.
Burton C; Beijing National Laboratory for Molecular Sciences, the Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Institute of Analytical Chemistry, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China.
Yang L; Department of Chemistry and Center for Single Cell, Single Nanoparticle, and Single Molecule Monitoring, Missouri University of Science and Technology, Rolla, MO, 65409, USA.
Nie H; Beijing National Laboratory for Molecular Sciences, the Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Institute of Analytical Chemistry, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China.
Tian Y; Analytical Instrumentation Center, Peking University, Beijing, 100871, China.
Bai Y; Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, 100871, China.
Liu H; Beijing National Laboratory for Molecular Sciences, the Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Institute of Analytical Chemistry, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China. yu.bai@pku.edu.cn.

Anal Bioanal Chem ; 408(11): 2963-73, 2016 Apr.

Article em En | MEDLINE | ID: mdl-26780709

Assuntos

Biomarcadores/metabolismo; Lipídeos/química; Serotonina/metabolismo; Triptofano Hidroxilase/metabolismo; Animais; Camundongos; Camundongos Knockout; Estresse Oxidativo; Triptofano Hidroxilase/genética

Palavras-chave

Lipid biomarkers; Lipidomics; Serotonin deficiency; Tryptophan hydroxylase 2 knockout (Tph2−/−) mice; Two-dimensional liquid chromatographyquadrupole time-of-flight mass spectrometry (2D LCQToF-MS)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triptofano Hidroxilase / Biomarcadores / Serotonina / Lipídeos Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: Anal Bioanal Chem Ano de publicação: 2016 Tipo de documento: Article País de afiliação: China

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