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Development of a RapidFire mass spectrometry assay and a fluorescence assay for the discovery of kynurenine aminotransferase II inhibitors to treat central nervous system disorders.
Lu, Hao; Kopcho, Lisa; Ghosh, Kaushik; Witmer, Mark; Parker, Michael; Gupta, Sumit; Paul, Marilyn; Krishnamurthy, Prasad; Laksmaiah, Basanth; Xie, Dianlin; Tredup, Jeffrey; Zhang, Litao; Abell, Lynn M.
Afiliação
  • Lu H; Lead Discovery and Optimization, Bristol-Myers Squibb R&D, Pennington, NJ 08534, USA. Electronic address: hao.lu@bms.com.
  • Kopcho L; Lead Discovery and Optimization, Bristol-Myers Squibb R&D, Pennington, NJ 08534, USA.
  • Ghosh K; Disease Sciences and Technology, Biocon Bristol-Myers Squibb R&D Centre, Bangalore, 560099, India.
  • Witmer M; Protein Science, Bristol-Myers Squibb R&D, Princeton, NJ 08648, USA.
  • Parker M; Discovery Chemistry, Bristol-Myers Squibb R&D, Wallingford, CT 06492, USA.
  • Gupta S; Disease Sciences and Technology, Biocon Bristol-Myers Squibb R&D Centre, Bangalore, 560099, India.
  • Paul M; Disease Sciences and Technology, Biocon Bristol-Myers Squibb R&D Centre, Bangalore, 560099, India.
  • Krishnamurthy P; Disease Sciences and Technology, Biocon Bristol-Myers Squibb R&D Centre, Bangalore, 560099, India.
  • Laksmaiah B; Disease Sciences and Technology, Biocon Bristol-Myers Squibb R&D Centre, Bangalore, 560099, India.
  • Xie D; Protein Science, Bristol-Myers Squibb R&D, Princeton, NJ 08648, USA.
  • Tredup J; Protein Science, Bristol-Myers Squibb R&D, Princeton, NJ 08648, USA.
  • Zhang L; Lead Discovery and Optimization, Bristol-Myers Squibb R&D, Pennington, NJ 08534, USA.
  • Abell LM; Lead Discovery and Optimization, Bristol-Myers Squibb R&D, Pennington, NJ 08534, USA. Electronic address: lynn.abell@bms.com.
Anal Biochem ; 501: 56-65, 2016 May 15.
Article em En | MEDLINE | ID: mdl-26874021
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Avaliação Pré-Clínica de Medicamentos / Inibidores Enzimáticos / Ensaios Enzimáticos / Transaminases Limite: Humans Idioma: En Revista: Anal Biochem Ano de publicação: 2016 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Avaliação Pré-Clínica de Medicamentos / Inibidores Enzimáticos / Ensaios Enzimáticos / Transaminases Limite: Humans Idioma: En Revista: Anal Biochem Ano de publicação: 2016 Tipo de documento: Article