Development of rare resistance-associated variants that are extremely tolerant against NS5A inhibitors during daclatasvir/asunaprevir therapy by a two-hit mechanism.

Uchida, Yoshihito; Kouyama, Jun-Ichi; Naiki, Kayoko; Sugawara, Kayoko; Inao, Mie; Imai, Yukinori; Nakayama, Nobuaki; Mochida, Satoshi

Uchida, Yoshihito; Kouyama, Jun-Ichi; Naiki, Kayoko; Sugawara, Kayoko; Inao, Mie; Imai, Yukinori; Nakayama, Nobuaki; Mochida, Satoshi.

Afiliação

Uchida Y; Department of Gastroenterology and Hepatology, Faculty of Medicine, Saitama Medical University, Moroyama, Japan.
Kouyama JI; Department of Gastroenterology and Hepatology, Faculty of Medicine, Saitama Medical University, Moroyama, Japan.
Naiki K; Department of Gastroenterology and Hepatology, Faculty of Medicine, Saitama Medical University, Moroyama, Japan.
Sugawara K; Department of Gastroenterology and Hepatology, Faculty of Medicine, Saitama Medical University, Moroyama, Japan.
Inao M; Department of Gastroenterology and Hepatology, Faculty of Medicine, Saitama Medical University, Moroyama, Japan.
Imai Y; Department of Gastroenterology and Hepatology, Faculty of Medicine, Saitama Medical University, Moroyama, Japan.
Nakayama N; Department of Gastroenterology and Hepatology, Faculty of Medicine, Saitama Medical University, Moroyama, Japan.
Mochida S; Department of Gastroenterology and Hepatology, Faculty of Medicine, Saitama Medical University, Moroyama, Japan.

Hepatol Res ; 46(12): 1234-1246, 2016 Nov.

Article em En | MEDLINE | ID: mdl-26878268

Palavras-chave

HCV; NS3/4A protease inhibitor; NS5A inhibitor; resistance-associated variants

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Risk_factors_studies Idioma: En Revista: Hepatol Res Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Japão

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