Plasma levels of endothelial and B-cell-derived microparticles are restored by fingolimod treatment in multiple sclerosis patients.
Mult Scler
; 22(14): 1883-1887, 2016 12.
Article
em En
| MEDLINE
| ID: mdl-26931477
ABSTRACT
BACKGROUND:
No molecular marker can monitor disease progression and treatment efficacy in multiple sclerosis (MS). Circulating microparticles represent a potential snapshot of disease activity at the blood brain barrier. OBJECTIVES ANDMETHODS:
To profile plasma microparticles by flow cytometry in MS and determine how fingolimod could impact endothelial microparticles production.RESULTS:
In non-treated MS patients compared to healthy and fingolimod-treated patients, endothelial microparticles were higher, while B-cell-microparticle numbers were lower. Fingolimod dramatically reduced tumour necrosis factor (TNF)-induced endothelial microparticle release in vitro.CONCLUSION:
Fingolimod restored dysregulated endothelial and B-cell-microparticle numbers, which could serve as a biomarker in MS.Palavras-chave
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Linfócitos B
/
Células Endoteliais
/
Micropartículas Derivadas de Células
/
Cloridrato de Fingolimode
/
Imunossupressores
/
Esclerose Múltipla
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Mult Scler
Assunto da revista:
NEUROLOGIA
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Austrália