Early Weight Loss during Chemoradiotherapy Has a Detrimental Impact on Outcome in NSCLC.
J Thorac Oncol
; 11(6): 873-9, 2016 06.
Article
em En
| MEDLINE
| ID: mdl-26940529
ABSTRACT
OBJECTIVES:
The aim of this study was to assess the effect of early weight loss before the onset of radiation esophagitis on overall survival (OS) in patients with non-small cell lung cancer treated with concurrent chemoradiotherapy.METHODS:
Characteristics (e.g., patient weight, radiation esophagitis score, sex, World Health Organization performance status, chemotherapy dose, nodal status, and gross tumor volume) of 151 patients who received concurrent chemoradiotherapy (in 2006-2013) were retrospectively correlated with OS. Early weight loss was defined as weight loss of more than 5% between the start and third week of radiotherapy in patients whose weight was stable before treatment initiation.RESULTS:
In 17% of the patients early weight loss was observed. Median OS (95% confidence interval [CI]) was significantly shorter in the early weight loss group (OS = 13.0 months, 95% CI 2.0-24.0) versus in the non-early weight loss group (OS = 23.0 months, 95% CI 14.7-31.3) (hazard ratio [HR] = 1.8, 95% CI 1.12-2.96, p = 0.017). On multivariate analysis sex (HR = 2.1, 95% CI 1.33-3.29, p = 0.001), World Health Organization performance status (HR = 1.9, 95% CI 1.20-2.97, p = 0.006), nodal status (HR = 2.9, 95% CI 1.38-6.01, p = 0.005), and early weight loss (HR = 1.9, 95% CI 1.10-3.19, p = 0.022) were associated with OS.CONCLUSIONS:
Early weight loss in patients with non-small cell lung cancer was found to be associated with worse prognosis. These data warrant further investigation into the efficacy of tailored intervention to prevent early weight loss.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Redução de Peso
/
Carcinoma Pulmonar de Células não Pequenas
/
Esofagite
/
Quimiorradioterapia
/
Neoplasias Pulmonares
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
J Thorac Oncol
Ano de publicação:
2016
Tipo de documento:
Article