RNA-sequencing analysis of core binding factor AML identifies recurrent ZBTB7A mutations and defines RUNX1-CBFA2T3 fusion signature.

Lavallée, Vincent-Philippe; Lemieux, Sébastien; Boucher, Geneviève; Gendron, Patrick; Boivin, Isabel; Armstrong, Richard N; Sauvageau, Guy; Hébert, Josée

Lavallée, Vincent-Philippe; Lemieux, Sébastien; Boucher, Geneviève; Gendron, Patrick; Boivin, Isabel; Armstrong, Richard N; Sauvageau, Guy; Hébert, Josée.

Afiliação

Lavallée VP; The Leucegene project at Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, QC, Canada; Division of Hematology, Maisonneuve-Rosemont Hospital, Montréal, QC, Canada;
Lemieux S; The Leucegene project at Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, QC, Canada; Department of Computer Science and Operations Research, Université de Montréal, Montréal, QC, Canada;
Boucher G; The Leucegene project at Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, QC, Canada;
Gendron P; The Leucegene project at Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, QC, Canada;
Boivin I; The Leucegene project at Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, QC, Canada;
Armstrong RN; The Leucegene project at Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, QC, Canada;
Sauvageau G; The Leucegene project at Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, QC, Canada; Division of Hematology, Maisonneuve-Rosemont Hospital, Montréal, QC, Canada; Quebec Leukemia Cell Bank, Maisonneuve-Rosemont Hospital, Montréal, QC, Canada; and Department of Medic
Hébert J; The Leucegene project at Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, QC, Canada; Division of Hematology, Maisonneuve-Rosemont Hospital, Montréal, QC, Canada; Quebec Leukemia Cell Bank, Maisonneuve-Rosemont Hospital, Montréal, QC, Canada; and Department of Medic

Blood ; 127(20): 2498-501, 2016 05 19.

Article em En | MEDLINE | ID: mdl-26968532

Assuntos

Subunidade alfa 2 de Fator de Ligação ao Core/genética; Proteínas de Ligação a DNA/genética; Leucemia Mieloide Aguda/genética; Mutação; Proteínas de Fusão Oncogênica/genética; Proteínas Repressoras/genética; Fatores de Transcrição/genética; Proteínas Supressoras de Tumor/genética; Adolescente; Adulto; Idoso; Idoso de 80 Anos ou mais; Estudos de Coortes; Feminino; Humanos; Masculino; Pessoa de Meia-Idade; RNA/genética; Transcriptoma; Adulto Jovem

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Repressoras / Fatores de Transcrição / Leucemia Mieloide Aguda / Proteínas de Fusão Oncogênica / Proteínas Supressoras de Tumor / Proteínas de Ligação a DNA / Subunidade alfa 2 de Fator de Ligação ao Core / Mutação Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Blood Ano de publicação: 2016 Tipo de documento: Article

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