Polymer Nanoparticles Modified with Photo- and pH-Dual-Responsive Polypeptides for Enhanced and Targeted Cancer Therapy.

Yang, Yang; Xie, Xiangyang; Yang, Yanfang; Li, Zhiping; Yu, Fanglin; Gong, Wei; Li, Ying; Zhang, Hui; Wang, Zhiyuan; Mei, Xingguo

Yang, Yang; Xie, Xiangyang; Yang, Yanfang; Li, Zhiping; Yu, Fanglin; Gong, Wei; Li, Ying; Zhang, Hui; Wang, Zhiyuan; Mei, Xingguo.

Afiliação

Yang Y; State Key Laboratory of Toxicology and Medical Countermeasure, Department of Pharmaceutics, Beijing Institute of Pharmacology and Toxicology , Beijing 100850, China.
Xie X; State Key Laboratory of Toxicology and Medical Countermeasure, Department of Pharmaceutics, Beijing Institute of Pharmacology and Toxicology , Beijing 100850, China.
Yang Y; Department of Pharmacy, Wuhan General Hospital of Guangzhou Command , Wuhan 430070, China.
Li Z; State Key Laboratory of Toxicology and Medical Countermeasure, Department of Pharmaceutics, Beijing Institute of Pharmacology and Toxicology , Beijing 100850, China.
Yu F; Beijing Key Laboratory of Drug Delivery Technology and Novel Formulation, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing 100050, China.
Gong W; State Key Laboratory of Toxicology and Medical Countermeasure, Department of Pharmaceutics, Beijing Institute of Pharmacology and Toxicology , Beijing 100850, China.
Li Y; State Key Laboratory of Toxicology and Medical Countermeasure, Department of Pharmaceutics, Beijing Institute of Pharmacology and Toxicology , Beijing 100850, China.
Zhang H; State Key Laboratory of Toxicology and Medical Countermeasure, Department of Pharmaceutics, Beijing Institute of Pharmacology and Toxicology , Beijing 100850, China.
Wang Z; State Key Laboratory of Toxicology and Medical Countermeasure, Department of Pharmaceutics, Beijing Institute of Pharmacology and Toxicology , Beijing 100850, China.
Mei X; State Key Laboratory of Toxicology and Medical Countermeasure, Department of Pharmaceutics, Beijing Institute of Pharmacology and Toxicology , Beijing 100850, China.

Mol Pharm ; 13(5): 1508-19, 2016 05 02.

Article em En | MEDLINE | ID: mdl-27043442

Assuntos

Peptídeos Penetradores de Células/química; Peptídeos Penetradores de Células/farmacologia; Nanopartículas/química; Neoplasias/tratamento farmacológico; Polímeros/química; Animais; Apoptose/efeitos dos fármacos; Linhagem Celular Tumoral; Portadores de Fármacos/química; Feminino; Técnicas de Transferência de Genes; Humanos; Concentração de Íons de Hidrogênio; Células MCF-7; Camundongos; Camundongos Endogâmicos BALB C; Camundongos Nus; Neoplasias/metabolismo; RNA Interferente Pequeno/metabolismo; Ensaios Antitumorais Modelo de Xenoenxerto/métodos

Palavras-chave

cell-penetrating peptides; photo- and pH-responsive polypeptides; small interfering RNA; tumor targeting nanoparticles

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polímeros / Nanopartículas / Peptídeos Penetradores de Células / Neoplasias Limite: Animals / Female / Humans Idioma: En Revista: Mol Pharm Assunto da revista: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: China

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