Serum levels of glial fibrillary acidic protein and Nogo-A in children with autism spectrum disorders.

ABSTRACT

CONTEXT Improved biomarkers would facilitate the diagnosis and treatment of autism spectrum disorders (ASD). OBJECTIVE: Our objective was to examine the levels of Nogo-A and glial fibrillary acidic protein (GFAP) in children with ASD. MATERIALS AND METHODS: Serum concentrations of GFAP and Nogo-A were determined by enzyme-linked immunosorbent assay. RESULTS: In this preliminary study, we found that serum Nogo-A was not found significantly different between groups, while serum levels of GFAP were significantly lower in ASD than controls. DISCUSSION AND CONCLUSIONS: It will be of great interest to determine other potential causes of elevated serum levels of GFAP, and whether this elevation has any phenotypic effect.