Critical analysis of carcinogenicity study outcomes. Relationship with pharmacological properties.

van der Laan, Jan Willem; Kasper, Peter; Silva Lima, Beatriz; Jones, David R; Pasanen, Markku

van der Laan, Jan Willem; Kasper, Peter; Silva Lima, Beatriz; Jones, David R; Pasanen, Markku.

Afiliação

van der Laan JW; a Medicines Evaluation Board , Utrecht , The Netherlands ;
Kasper P; b Federal Institute for Drugs and Medical Devices (BfArM) , Bonn , Germany ;
Silva Lima B; c Faculty of Pharmacy , Universidade De Lisboa , Lisbon , Portugal ;
Jones DR; d Medicines and Healthcare Products Regulatory Agency , London , UK ;
Pasanen M; e Faculty of Health Sciences, School of Pharmacy , University of Eastern Finland , Kuopio , Finland.

Crit Rev Toxicol ; 46(7): 587-614, 2016 08.

Article em En | MEDLINE | ID: mdl-27116466

Assuntos

Carcinógenos/toxicidade; Fenômenos Farmacológicos; Animais; Testes de Carcinogenicidade; Humanos; Preparações Farmacêuticas; Ratos

Palavras-chave

Carcinogenicity; NEGCARC paradigm; human pharmaceuticals; pharmacology; regulatory assessment

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinógenos / Fenômenos Farmacológicos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Crit Rev Toxicol Assunto da revista: TOXICOLOGIA Ano de publicação: 2016 Tipo de documento: Article

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