Co-expression network analysis prioritizes signaling pathways regulating liver regeneration after partial hepatectomy in rats.
Genet Mol Res
; 15(2)2016 Apr 04.
Article
em En
| MEDLINE
| ID: mdl-27173195
ABSTRACT
The liver has extraordinary powers of regeneration following partial hepatectomy (PH). Changes in gene expression levels play a key role in cell proliferation and differentiation during liver regeneration (LR). To understand the molecular mechanisms underlying LR, this study was designed to assess the time-dependent changes in rat hepatic gene expression. We obtained a gene expression profile of rat LR with high temporal resolution. We then constructed gene co-expression networks of regenerating liver tissue and identified 13 LR-specific modules from 1772 differentially expressed genes, and prioritized signaling pathways that regulated LR after PH. The results indicated that adipocytokine signaling, histone acetylation, and IL-6-related pathways play an important role in LR. Co-expression network analysis provides novel insight into understanding the molecular mechanisms behind LR.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
/
Redes Reguladoras de Genes
/
Fígado
/
Regeneração Hepática
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Genet Mol Res
Assunto da revista:
BIOLOGIA MOLECULAR
/
GENETICA
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
China