Herpes simplex encephalitis as a complication of neurosurgical procedures: report of 3 cases and review of the literature.
Virol J
; 13: 83, 2016 May 23.
Article
em En
| MEDLINE
| ID: mdl-27216026
ABSTRACT
BACKGROUND:
Herpes simplex virus (HSV) is the most common identified cause of focal encephalitis worldwide. However, postoperative HSV encephalitis (HSVE) is a rare complication of neurosurgical procedures and a significant clinical challengeMETHOD:
We describe 3 cases of postoperative HSVE and review all published reports. A total of 23 cases were identified.DISCUSSION:
Clinical heterogeneity represents a diagnostic challenge in the postoperative setting. Cerebral magnetic resonance imaging showed typical findings in a minority of patients only, whereas HSV-specific polymerase chain reaction on the cerebrospinal fluid proved to be a valuable test. The postoperative viral pathophysiology remains a subject of debate. The rate of adverse outcome is high and early antiviral treatment seems to be a strong predictor of clinical outcome.CONCLUSION:
We recommend early empirical treatment for any patient presenting with post-neurosurgical lymphocytic meningo-encephalitis, and prophylactic antiviral treatment for patients with a history of previous HSVE who will undergo a neurosurgical procedure.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Complicações Pós-Operatórias
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Procedimentos Neurocirúrgicos
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Encefalite por Herpes Simples
Tipo de estudo:
Prognostic_studies
Limite:
Adult
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Child
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Female
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Humans
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Infant
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Male
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Middle aged
Idioma:
En
Revista:
Virol J
Assunto da revista:
VIROLOGIA
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Suíça