Novel insights into the mechanisms of mitotic spindle assembly by NEK kinases.

Prosser, Suzanna L; O'Regan, Laura; Fry, Andrew M

Prosser, Suzanna L; O'Regan, Laura; Fry, Andrew M.

Afiliação

Prosser SL; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital , Toronto, Ontario, Canada.
O'Regan L; University of Leicester, Department of Biochemistry , Leicester, UK.
Fry AM; University of Leicester, Department of Biochemistry , Leicester, UK.

Mol Cell Oncol ; 3(3): e1062952, 2016 May.

Article em En | MEDLINE | ID: mdl-27314078

ABSTRACT

ABSTRACT

The mitotic spindle is the apparatus upon which chromosomes are segregated during cell division. We have discovered new roles for two members of the NIMA-related kinase (NEK) family in different molecular processes of spindle assembly. Moreover, loss of these proteins leads to segregation errors that drive cancer progression.

Palavras-chave

Centrosome separation; Hsp72; Nek5; Nek6; mitosis; spindle assembly

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Mol Cell Oncol Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Canadá

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