Physicochemical and Pharmacokinetic Characterization of Amorphous Solid Dispersion of Meloxicam with Enhanced Dissolution Property and Storage Stability.

Ochi, Masanori; Kimura, Keisuke; Kanda, Atsushi; Kawachi, Takaki; Matsuda, Akitoshi; Yuminoki, Kayo; Hashimoto, Naofumi

Ochi, Masanori; Kimura, Keisuke; Kanda, Atsushi; Kawachi, Takaki; Matsuda, Akitoshi; Yuminoki, Kayo; Hashimoto, Naofumi.

Afiliação

Ochi M; Department of Pharmaceutical Physicochemistry, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka, 573-0101, Japan. 12d403om@edu.setsunan.ac.jp.
Kimura K; Department of Pharmaceutical Physicochemistry, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka, 573-0101, Japan.
Kanda A; Department of Pharmaceutical Physicochemistry, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka, 573-0101, Japan.
Kawachi T; Department of Pharmaceutical Physicochemistry, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka, 573-0101, Japan.
Matsuda A; Department of Pharmaceutical Physicochemistry, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka, 573-0101, Japan.
Yuminoki K; Department of Pharmaceutical Physicochemistry, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka, 573-0101, Japan.
Hashimoto N; Department of Pharmaceutical Physicochemistry, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka, 573-0101, Japan.

AAPS PharmSciTech ; 17(4): 932-9, 2016 Aug.

Article em En | MEDLINE | ID: mdl-27435198

Assuntos

Tiazinas/química; Tiazinas/farmacocinética; Tiazóis/química; Tiazóis/farmacocinética; Administração Oral; Animais; Disponibilidade Biológica; Química Farmacêutica; Cristalização/métodos; Composição de Medicamentos/métodos; Estabilidade de Medicamentos; Espectroscopia de Ressonância Magnética/métodos; Masculino; Meloxicam; Polímeros/química; Polímeros/farmacocinética; Ácidos Polimetacrílicos/química; Ratos; Ratos Sprague-Dawley; Solubilidade; Espectrofotometria Infravermelho/métodos

Palavras-chave

FTIR; amorphous; dissolution; interaction; stability

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tiazinas / Tiazóis Limite: Animals Idioma: En Revista: AAPS PharmSciTech Assunto da revista: FARMACOLOGIA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Japão

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