Aortic elasticity indices by magnetic resonance predict progression of ascending aorta dilation.
Eur Radiol
; 27(4): 1395-1403, 2017 Apr.
Article
em En
| MEDLINE
| ID: mdl-27456964
ABSTRACT
OBJECTIVES:
Aortic distensibility and pulse-wave velocity (PWV) are under investigation as parameters by which to evaluate the indication for ascending aorta (AA) replacement. The maximum rate of systolic distension (MRSD) was proposed as a new index of aortic elasticity. The aim of this study was to assess the role of aortic elasticity parameters to predict AA growth rates in patients with AA dilation (AAD).METHODS:
Magnetic resonance imaging (MRI) was performed annually in 65 patients with AA dilation (median follow-up 17 months; 25-75th percentile; range 12-30 months). A significant increase in AA diameter was defined as a ≥2-mm increase.RESULTS:
An increase in AA diameter was found in 42 (68 %) patients (AAD+ group) and absent in 20. Median increase was 0.16 (25-75th percentile; range 0.32-0.7) mm/month. The AAD+ group had a lower MRSD (4.6 ± 2.2 vs 7.4 ± 2.0, p < 0.001) but the same PWV and distensibility. MRSD showed 93.7 % specificity and 75.6 % sensitivity for prediction of increase. Patients with MRSD ≤ 6 had lower progression-free survival times (p < 0.002). After a follow-up of 4.1 years, patients who underwent surgical therapy had lower MRSD and distensibility than others.CONCLUSIONS:
MRSD is an index of aorta elastic properties and is a valuable predictor for progression in AAD. KEY POINTS ⢠MRI-derived parameters of aortic wall elasticity predict progression of ascending aorta dilation. ⢠Maximal rate of systolic distension (MRSD) was the best predictor of progression. ⢠Patients with MRSD ≤ 6 had lower progression-free survival (PFS) times. ⢠Patients who underwent surgical therapy had lower MRSD and distensibility. ⢠MRI-derived parameters identify patients with fast progression of Ascending Aorta Dilation.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Aorta
/
Aneurisma Aórtico
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Imageamento por Ressonância Magnética
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Elasticidade
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
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Prognostic_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Eur Radiol
Assunto da revista:
RADIOLOGIA
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Itália