Anti-Ma and anti-Ma2-associated paraneoplastic neurological syndromes. / Síndromes neurológicos paraneoplásicos asociados a anticuerpos anti-Ma y anti-Ma2.
Neurologia (Engl Ed)
; 33(1): 18-27, 2018.
Article
em En, Es
| MEDLINE
| ID: mdl-27460184
ABSTRACT
OBJECTIVE:
Analyse the clinical profile, associated tumour types, and response to treatment of paraneoplastic neurological syndromes associated with antibodies against Ma proteins.METHODS:
A retrospective study of patients with antibodies against Ma proteins identified in a neuroimmunology laboratory of reference.RESULTS:
Of the 32 patients identified, 20 showed reactivity against Ma2 only (anti-Ma2 antibodies), 11 against Ma1 and Ma2 (anti-Ma antibodies), and 1 with reactivity against Ma1 only (anti-Ma1 antibodies). The most common clinical presentations were limbic encephalopathy, diencephalic dysfunction, or brainstem encephalopathy, frequently appearing as a combination of these features. Three patients had isolated cerebellar dysfunction with anti-Ma antibodies, and 2 exhibited peripheral nervous system syndrome with anti-Ma2 antibodies. Testicular tumours were the most common neoplasms (40%) in the anti-Ma2 cases. In the group associated with anti-Ma1 antibodies, the most common were lung tumours (36%), followed by testicular tumours. All idiopathic cases were reactive to Ma2. The clinical outcome was significantly better in the anti-Ma2 group. The patient with anti-Ma1 presented with limbic encephalitis and brainstem dysfunction associated with lymphoepithelioma of the bladder.CONCLUSIONS:
Specifically determining the different reactivities of anti-Ma protein antibodies in order to differentiate between Ma1 and Ma2 antibodies is important because anti-Ma2-associated paraneoplastic syndromes have a better outcome. Lastly, this study is the first to confirm that there may be cases that react exclusively to antibodies against Ma1.Palavras-chave
Texto completo:
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Autoanticorpos
/
Encefalite Límbica
/
Antígenos
/
Antígenos de Neoplasias
/
Proteínas do Tecido Nervoso
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Europa
Idioma:
En
/
Es
Revista:
Neurologia (Engl Ed)
Ano de publicação:
2018
Tipo de documento:
Article